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Fluocinolone, Hydroquinone, and Tretinoin

Generic Name: Fluocinolone, Hydroquinone, and Tretinoin (floo oh SIN oh lone, HYE droe kwin one, & TRET i noyn)
Brand Name: Tri-Luma

Medically reviewed on July 4, 2018

Uses of Fluocinolone, Hydroquinone, and Tretinoin:

  • It is used to lighten the color of some dark patches on the skin.

What do I need to tell my doctor BEFORE I take Fluocinolone, Hydroquinone, and Tretinoin?

  • If you have an allergy to fluocinolone, hydroquinone, tretinoin, or any other part of fluocinolone, hydroquinone, and tretinoin.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take fluocinolone, hydroquinone, and tretinoin with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Fluocinolone, Hydroquinone, and Tretinoin?

  • Tell all of your health care providers that you take fluocinolone, hydroquinone, and tretinoin. This includes your doctors, nurses, pharmacists, and dentists.
  • If you are allergic to sulfites, talk with your doctor. Some products have sulfites.
  • After stopping fluocinolone, hydroquinone, and tretinoin, some of the color change may come back.
  • Some weather conditions may irritate the skin. Talk with the doctor.
  • Use of other skin products while using fluocinolone, hydroquinone, and tretinoin may cause more irritation.
  • Talk with your doctor before you use other drugs or products on your skin.
  • Practice good skin care and avoid the sun.
  • Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
  • If you use birth control, use a non-hormone type of birth control like condoms to prevent pregnancy. Birth control pills and other hormone-based birth control can cause some dark patches of skin to get worse.
  • This medicine may cause harm to the unborn baby or loss of the unborn baby if you take it while you are pregnant.
  • If you are pregnant or you get pregnant while taking fluocinolone, hydroquinone, and tretinoin, call your doctor right away.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Fluocinolone, Hydroquinone, and Tretinoin) best taken?

Use fluocinolone, hydroquinone, and tretinoin as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Do not take fluocinolone, hydroquinone, and tretinoin by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
  • Put on at least 30 minutes before you go to bed.
  • Wash your hands before and after use.
  • Clean affected part before use. Make sure to dry well.
  • Put a thin layer on the affected skin and rub in gently.
  • Do not put on open wounds.
  • Do not put on cuts, scrapes, or damaged skin.
  • Do not use coverings (bandages, dressings) unless told to do so by the doctor.

What do I do if I miss a dose?

  • Put on a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not put on 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of a weak adrenal gland like a very bad upset stomach or throwing up, very bad dizziness or passing out, muscle weakness, feeling very tired, mood changes, not hungry, or weight loss.
  • Signs of Cushing's disease like weight gain in the upper back or belly, moon face, very bad headache, or slow healing.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Very bad skin irritation.
  • Change in color of skin to blue-black.
  • Skin changes (pimples, stretch marks, slow healing, hair growth).
  • Skin swelling.
  • Crusting.

What are some other side effects of Fluocinolone, Hydroquinone, and Tretinoin?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dry skin.
  • Itching.
  • Burning.
  • Redness.
  • Peeling.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Fluocinolone, Hydroquinone, and Tretinoin?

  • Store in a refrigerator. Do not freeze.
  • Keep lid tightly closed.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about fluocinolone, hydroquinone, and tretinoin, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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