Estrogens (Conjugated Equine) and Bazedoxifene
Generic Name: Estrogens (Conjugated/Equine) and Bazedoxifene (ES troe jenz, KON joo gate ed/EE kwine & ba ze DOX i feen)
Brand Name: Duavee
Medically reviewed on Feb 14, 2019
- Do not take other estrogens, a progestin, or other drugs like bazedoxifene while taking estrogens (conjugated/equine) and bazedoxifene.
- Estrogens may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to the doctor.
- Do not use estrogens to prevent heart disease or dementia. Using estrogens may raise the chances of having a heart attack, a stroke, breast cancer, ovarian cancer, a blood clot, or dementia.
- Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.
Uses of Estrogens and Bazedoxifene:
- It is used to treat symptoms of low estrogen levels in women who have been through menopause (change of life).
- It is used to treat soft, brittle bones (osteoporosis) in women after change of life.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Estrogens and Bazedoxifene?
- If you have an allergy to estrogens, bazedoxifene, or any other part of estrogens (conjugated/equine) and bazedoxifene.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are pregnant or may be pregnant. Do not take estrogens (conjugated/equine) and bazedoxifene if you are pregnant.
- If you are breast-feeding. Do not breast-feed while you take estrogens (conjugated/equine) and bazedoxifene.
- If you have had any of these health problems: Bleeding disorder, blood clots, a higher risk of having a blood clot, breast cancer, liver problems or liver tumor, heart attack, stroke, or a tumor where estrogen makes it grow.
- If you have unexplained vaginal bleeding.
- If you have kidney disease.
- If you have not been through menopause or you are still able to have a baby.
- If you are older than 75 years of age. This medicine is not approved for use in people older than 75 years of age.
- If the patient is a child. Do not give estrogens (conjugated/equine) and bazedoxifene to a child.
This is not a list of all drugs or health problems that interact with estrogens (conjugated/equine) and bazedoxifene.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take estrogens (conjugated/equine) and bazedoxifene with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Estrogens and Bazedoxifene?
- Tell all of your health care providers that you take estrogens (conjugated/equine) and bazedoxifene. This includes your doctors, nurses, pharmacists, and dentists.
- This medicine may raise the chance of blood clots, a stroke, or a heart attack. Talk with the doctor.
- Talk with your doctor if you will need to be still for long periods of time like long trips, bedrest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.
- If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
- High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
- High triglyceride levels have happened with estrogens (conjugated/equine) and bazedoxifene. Tell your doctor if you have ever had high triglyceride levels.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Have a bone density test as you have been told by your doctor. Talk with your doctor.
- Be sure to have regular breast exams and gynecology check-ups. Your doctor will tell you how often to have these. You will also need to do breast self-exams as your doctor has told you. Talk with your doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take estrogens (conjugated/equine) and bazedoxifene.
- Do not smoke. Smoking raises the chance of heart disease. Talk with your doctor.
- Limit your drinking of alcohol.
- If you are 65 or older, use estrogens (conjugated/equine) and bazedoxifene with care. You could have more side effects.
How is this medicine (Estrogens and Bazedoxifene) best taken?
Use estrogens (conjugated/equine) and bazedoxifene as ordered by your doctor. Read all information given to you. Follow all instructions closely.
For all uses of estrogens (conjugated/equine) and bazedoxifene:
- Take with or without food.
- Swallow whole. Do not chew, break, or crush.
- Do not take estrogens (conjugated/equine) and bazedoxifene out of the blister pack until you are ready to take it. Take estrogens (conjugated/equine) and bazedoxifene right away after opening the blister pack. Do not store the removed drug for future use.
- To gain the most benefit, do not miss doses.
- Keep taking estrogens (conjugated/equine) and bazedoxifene as you have been told by your doctor or other health care provider, even if you feel well.
Soft, brittle bones (osteoporosis):
- Take calcium and vitamin D as you were told by your doctor.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- If you are not sure what to do if you miss a dose, call your doctor.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Signs of gallbladder problems like pain in the upper right belly area, right shoulder area, or between the shoulder blades; yellow skin or eyes; fever with chills; bloating; or very upset stomach or throwing up.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Very upset stomach or throwing up.
- Very bad belly pain.
- Vaginal bleeding that is not normal.
- Vaginal itching or discharge.
- Bulging eyes.
- Change in how contact lenses feel in the eyes.
- Change in eyesight.
- Loss of eyesight.
- Low mood (depression).
- Mood changes.
- Memory problems or loss.
- Feeling very tired or weak.
- Breast pain.
- A lump in the breast, breast soreness, or nipple discharge.
- Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.
What are some other side effects of Estrogens and Bazedoxifene?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Estrogens and Bazedoxifene?
- Store in the original container at room temperature.
- Store in a dry place. Do not store in a bathroom.
- After opening, throw away any part not used after 60 days.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about estrogens (conjugated/equine) and bazedoxifene, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about bazedoxifene/conjugated estrogens
- Bazedoxifene/conjugated estrogens Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 12 Reviews
- Drug class: sex hormone combinations
Other brands: Duavee
- Bazedoxifene Acetate (AHFS Monograph)
- Estrogens (Conjugated/Equine) and Bazedoxifene (Wolters Kluwer)