Generic Name: Estradiol Topical Emulsion (ES tra DYE ol)
Brand Name: Estrasorb
Medically reviewed on May 2, 2018.
- Estrogens may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to the doctor.
- Do not use estrogens to prevent heart disease or dementia. Using estrogens may raise the chances of having a heart attack, a stroke, breast cancer, ovarian cancer, a blood clot, or dementia.
- Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.
Uses of Estradiol Topical Emulsion:
- It is used to prevent or lower the signs of the change of life (menopause).
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Estradiol Topical Emulsion?
- If you have an allergy to estradiol or any other part of estradiol topical emulsion.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have ever had a very bad or life-threatening reaction called angioedema. Signs may be swelling of the hands, face, lips, eyes, tongue, or throat; trouble breathing; trouble swallowing; unusual hoarseness.
- If you have had any of these health problems: Bleeding disorder, blood clots, a higher risk of having a blood clot, breast cancer, liver problems or liver tumor, heart attack, stroke, or a tumor where estrogen makes it grow.
- If you have eyesight problems like loss of eyesight from blood vessel problems in the eye.
- If you have cancer of the endometrium (lining of the uterus).
- If you have unexplained vaginal bleeding.
- If you are pregnant or may be pregnant. Do not take estradiol topical emulsion if you are pregnant.
This is not a list of all drugs or health problems that interact with estradiol topical emulsion.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take estradiol topical emulsion with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Estradiol Topical Emulsion?
- Tell all of your health care providers that you take estradiol topical emulsion. This includes your doctors, nurses, pharmacists, and dentists.
- This medicine may raise the chance of blood clots, a stroke, or a heart attack. Talk with the doctor.
- Talk with your doctor if you will need to be still for long periods of time like long trips, bedrest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.
- If you are allergic to tartrazine, talk with your doctor. Some products have tartrazine.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
- High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Have a bone density test as you have been told by your doctor. Talk with your doctor.
- Be sure to have regular breast exams and gynecology check-ups. Your doctor will tell you how often to have these. You will also need to do breast self-exams as your doctor has told you. Talk with your doctor.
- This medicine may cause dark patches of skin on your face. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take estradiol topical emulsion.
- Do not smoke. Smoking raises the chance of heart disease. Talk with your doctor.
- Limit your drinking of alcohol.
- If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
- This medicine may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor.
- Talk with your doctor before you use other drugs or products on your skin.
- Do not use sunscreen at the same time you put estradiol topical emulsion on.
- If you are 65 or older, use estradiol topical emulsion with care. You could have more side effects.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Estradiol Topical Emulsion) best taken?
Use estradiol topical emulsion as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Do not take estradiol topical emulsion by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
- Use estradiol topical emulsion at the same time of day.
- Do not use on skin that has any problems.
- Do not put on the face, breast, or vagina.
- Wash your hands before and after use.
- Do not let any other person touch the gel, solution, or the treated part of your skin.
- Put on clean, dry, healthy skin.
- Put contents of 1 pouch on 1 thigh. Rub into thigh and calf.
- Put contents of the second pouch on the other thigh. Rub into thigh and calf.
- Let dry before covering with clothing.
What do I do if I miss a dose?
- Use a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not use 2 doses or extra doses.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Chest pain or pressure.
- Shortness of breath.
- Coughing up blood.
- Swelling, warmth, numbness, change of color, or pain in a leg or arm.
- Very bad headache.
- Very bad dizziness or passing out.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Very upset stomach or throwing up.
- Very bad belly pain.
- Back pain.
- Bulging eyes.
- Change in how contact lenses feel in the eyes.
- Loss of eyesight.
- Change in eyesight.
- A lump in the breast, breast soreness, or nipple discharge.
- Breast pain.
- Vaginal itching or discharge.
- Vaginal bleeding that is not normal.
- Low mood (depression).
- Mood changes.
- Memory problems or loss.
- Not able to pass urine or change in how much urine is passed.
- Pain when passing urine.
What are some other side effects of Estradiol Topical Emulsion?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Hair loss.
- Upset stomach or throwing up.
- Enlarged breasts.
- Breast soreness.
- Vaginal bleeding or spotting.
- Painful periods.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Estradiol Topical Emulsion?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about estradiol topical emulsion, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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