Generic Name: esomeprazole (ES-oh-MEP-ra-zole)
Brand Name: Nexium
Esomeprazole suspension is used for:
Treating heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD). It may also be used to prevent stomach ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs). It may also be used with certain antibiotics to treat ulcers of the small intestine and to prevent them from coming back. It may also be used to treat conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It may also be used for other conditions as determined by your doctor.
Esomeprazole suspension is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced in the stomach.
Do NOT use esomeprazole suspension if:
- you are allergic to any ingredient in esomeprazole suspension or to any similar medicine (eg, omeprazole)
- you are taking atazanavir, clopidogrel, dasatinib, nelfinavir, rifampin, rilpivirine, or St. John's wort
Contact your doctor or health care provider right away if any of these apply to you.
Before using esomeprazole suspension:
Some medical conditions may interact with esomeprazole suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have low blood potassium or magnesium levels, low blood vitamin B12 levels or vitamin B12 deficiency, liver problems, or stomach or bowel cancer
- if you have osteoporosis (weak bones), a family history of osteoporosis, or other risk factors of osteoporosis (eg, smoking, poor nutrition)
Some MEDICINES MAY INTERACT with esomeprazole suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood magnesium levels may be increased
- Voriconazole because it may increase the risk of esomeprazole suspension's side effects
- Ginkgo biloba, rifampin, or St. John's wort because they may decrease esomeprazole suspension's effectiveness
- Anticoagulants (eg, warfarin), cilostazol, diazepam, digoxin, methotrexate, saquinavir, or tacrolimus because the risk of their side effects may be increased by esomeprazole suspension
- Atazanavir , bosutinib, clopidogrel, dasatinib, erlotinib, indinavir, iron, itraconazole, ketoconazole, mycophenolate, nelfinavir, nilotinib, posaconazole, rilpivirine, or sorafenib because their effectiveness may be decreased by esomeprazole suspension
This may not be a complete list of all interactions that may occur. Ask your health care provider if esomeprazole suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use esomeprazole suspension:
Use esomeprazole suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Esomeprazole suspension comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get esomeprazole suspension refilled.
- Take esomeprazole suspension by mouth on an empty stomach at least 1 hour before a meal.
- You will need to mix esomeprazole suspension in a small amount of water before taking your dose. You should use an oral syringe to measure the amount of water needed to mix your dose. Ask your pharmacist for an oral syringe. The recommended amount of water for the mixing of each dose is as follows:
- If your dose of esomeprazole suspension is 2.5 or 5 mg, add 1 teaspoon (5 mL) of water to a container.
- If your dose of esomeprazole suspension is 10, 20, or 40 mg, add 1 tablespoon (15 mL) of water to a container
- Tear open the medicine packet and add the contents of the packet to the container. Stir well. Allow the mixture to thicken for 2 to 3 minutes. Stir again. Drink the mixture within 30 minutes. If it is not used within 30 minutes, throw away this dose and mix a new dose. If any medicine remains in the glass after drinking, add more water. Stir and then drink right away.
- If the patient is taking esomeprazole suspension through a nasogastric (NG) tube or gastric tube, follow the instructions for use in the extra patient leaflet.
- If your doctor has instructed you to use more than 1 packet for your dose, follow the mixing instructions provided by your doctor or pharmacist.
- You may take antacids while you are using esomeprazole suspension if you are directed to do so by your doctor.
- Continue to take esomeprazole suspension even if you feel well. Do not miss any doses.
- If you miss a dose of esomeprazole suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use esomeprazole suspension.
Important safety information:
- Esomeprazole suspension may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use esomeprazole suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do NOT change your dose, stop taking esomeprazole suspension, or take esomeprazole suspension for longer than prescribed without checking with your doctor.
- Contact your doctor if you have any symptoms of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds, or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing.
- Esomeprazole suspension may increase the risk of a serious form of diarrhea. Contact your doctor right away if stomach pain or cramps, severe or persistent diarrhea, or bloody or watery stools occur. Discuss any questions or concerns with your doctor.
- Esomeprazole suspension may increase the risk of hip, wrist, and spine fractures in patients with weak bones (osteoporosis). The risk may be greater if you use esomeprazole suspension in high doses or for longer than a year, or if you are older than 50 years old. Contact your doctor if you have any questions about this information.
- Low blood magnesium levels have been reported rarely in patients taking PPIs for at least 3 months. In most cases, this effect was seen after a year of treatment. If you will be taking esomeprazole suspension for a long time, or if you take certain other medicines (eg, digoxin, diuretics), your doctor may perform lab tests to check for low blood magnesium levels. Seek medical attention right away if you experience symptoms of low blood magnesium levels (eg, dizziness; fast or irregular heartbeat; involuntary muscle movements; jitteriness or tremors; muscle aches, cramps, pain, spasms, or weakness; seizures).
- Long-term treatment (eg, longer than 3 years) with medicines like this one has rarely caused low vitamin B12 levels. Discuss any questions or concerns with your doctor.
- Check with your doctor to see whether you should take a calcium and vitamin D supplement while you take esomeprazole suspension.
- Esomeprazole suspension may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking esomeprazole suspension.
- Use esomeprazole suspension with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures.
- Caution is advised when using esomeprazole suspension in CHILDREN; they may be more likely to experience drowsiness from esomeprazole suspension.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using esomeprazole suspension while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking esomeprazole suspension.
Possible side effects of esomeprazole suspension:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; drowsiness; dry mouth; gas; headache; mild diarrhea or stomach pain; nausea.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or watery stools; bone pain; chest pain; confusion; dark urine; difficult or painful urination; fast heartbeat; fever, chills, or persistent sore throat; mental or mood changes (eg, depression); red, swollen, blistered, or peeling skin; severe or persistent diarrhea or stomach pain; severe or persistent nausea or vomiting; shortness of breath; sluggishness; sore joints; stomach cramps; swelling of the hands, ankles, or feet; symptoms of kidney problems (eg, not able to pass urine, change in the amount of urine produced, blood in the urine, a big weight gain); unexplained weight loss; unusual bruising or bleeding; unusual tiredness or weakness; vision changes; yellowing of the eyes or skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of esomeprazole suspension:
Store esomeprazole suspension at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep esomeprazole suspension out of the reach of children and away from pets.
- If you have any questions about esomeprazole suspension, please talk with your doctor, pharmacist, or other health care provider.
- Esomeprazole suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take esomeprazole suspension or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about esomeprazole suspension. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to esomeprazole suspension. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using esomeprazole suspension.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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