Generic Name: lamivudine (la-MIV-ue-deen)
Brand Name: Epivir
Epivir solution may cause severe and sometimes fatal liver problems or high blood acid levels (lactic acidosis). Contact your doctor right away if you develop yellowing of the skin or eyes; dark urine; pale stools; stomach pain; nausea; vomiting; diarrhea; persistent loss of appetite; fast or difficult breathing; slow or irregular heartbeat; unusual weakness or tiredness; muscle pain or tenderness; unusual feeling of cold (eg, in arms or legs); or unusual drowsiness, dizziness, or light-headedness.
Some patients with both hepatitis B virus (HBV) and HIV infection who took Epivir solution experienced severe worsening of HBV infection after they stopped it. Patients who have both HBV and HIV infection need close medical follow-up to check for worsening liver problems for at least several months after they stop Epivir solution. Keep all doctor and lab appointments. Do not stop taking Epivir solution without checking with your doctor.
Epivir solution contains a higher dose of the same ingredient found in Epivir-HBV. Do not switch between Epivir and Epivir-HBV without checking with your doctor. Epivir-HBV does not contain the correct amount of medicine to treat HIV infection.
Epivir solution is used for:
Treating HIV infection in combination with other medicines.
Epivir solution is a nucleoside analogue. It works by blocking the growth of HIV.
Do NOT use Epivir solution if:
- you are allergic to any ingredient in Epivir solution
- you have an enlarged liver, abnormal liver function tests, or high levels of lactic acid in the blood (lactic acidosis)
- you are taking emtricitabine, zalcitabine, or another medicine containing lamivudine
Contact your doctor or health care provider right away if any of these apply to you.
Before using Epivir solution:
Some medical conditions may interact with Epivir solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of muscle problems, pancreas problems, abnormal blood cell counts, liver disease (eg, hepatitis) or other liver problems (eg, abnormal liver function tests), lactic acidosis, kidney problems, diabetes, or a nerve disorder
- if you are very overweight
- if the patient is a child who has a history of pancreas problems or who has previously taken other medicine for HIV infection
Some MEDICINES MAY INTERACT with Epivir solution. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Interferon alfa or ribavirin because severe liver problems may occur
- Emtricitabine, other medicines that contain lamivudine, or trimethoprim because they may increase the risk of Epivir solution's side effects
- Zalcitabine because it may decrease Epivir solution's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if Epivir solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Epivir solution:
Use Epivir solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Epivir solution. Talk to your pharmacist if you have questions about this information.
- Take Epivir solution by mouth with or without food.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Continue to take Epivir solution even if you feel well. Do not miss any doses.
- Taking Epivir solution at the same time each day will help you remember to take it.
- If you miss a dose of Epivir solution, take it as soon as possible. If it is within 2 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Epivir solution.
Important safety information:
- Tell your doctor or dentist that you take Epivir solution before you receive any medical or dental care, emergency care, or surgery.
- When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Epivir solution, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
- Epivir solution is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
- Epivir solution does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.
- Epivir solution may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start Epivir solution.
- Cases of worsening liver disease have been reported when Epivir solution is stopped in patients with both HIV and HBV infection. Discuss any medicine changes with your doctor.
- If you have HBV infection, your doctor will perform lab tests for several months after you stop taking Epivir solution. Some patients have had worsening HBV after stopping use of Epivir solution. Tell your doctor about any new or unusual symptoms that you notice after stopping treatment.
- Diabetes patients - Epivir solution contains sucrose and may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Epivir solution. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.
- Lab tests may be performed while you use Epivir solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Epivir solution with caution in CHILDREN; they may be more likely to experience certain side effects, including pancreas problems, wheezing, ear pain or swelling, or swollen lymph nodes.
- If your child is taking Epivir solution, the dose may need to be changed as your child's weight changes. Have your child's weight checked often. Talk with the doctor before changing your child's dose.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Epivir solution while you are pregnant. Epivir solution is found in breast milk. Do not breast-feed while taking Epivir solution. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Epivir solution to the baby.
Possible side effects of Epivir solution:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Cough; diarrhea; dizziness; general body discomfort; headache; loss of appetite; mild mouth pain or swelling; muscle or joint pain; nausea; runny/stuffy nose; stomach pain or cramps; tiredness; trouble sleeping; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling sensation; dark urine; ear pain or discharge; fever, chills, or sore throat; mental or mood changes; pale stools; persistent loss of appetite; severe or persistent muscle pain, ache, or tenderness; severe or persistent nausea, vomiting, or diarrhea; severe or persistent stomach pain or tenderness; swollen lymph nodes; symptoms of lactic acidosis (eg, fast or difficult breathing; fast, slow, or irregular heartbeat; severe or persistent weakness or tiredness; unusual drowsiness, dizziness, or light-headedness; unusual feeling of cold in the arms or legs; wheezing); yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Epivir solution:
Store Epivir solution at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in a tightly closed bottle away from heat, moisture, and light. Do not store in the bathroom. Keep Epivir solution out of the reach of children and away from pets.
- If you have any questions about Epivir solution, please talk with your doctor, pharmacist, or other health care provider.
- Epivir solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Epivir solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Epivir solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Epivir solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Epivir solution.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Epivir (lamivudine)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 1 Review – Add your own review/rating
- Generic Availability