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EndaCof-C

Generic Name: Codeine and Chlorpheniramine Liquid (KOE deen & KLOR fen IR a meen)
Brand Name: Codar AR, EndaCof-C, Lexuss 210, Z-Tuss AC

Medically reviewed: April 4, 2018

Warning

For all patients taking this medicine:
  • This medicine has an opioid drug in it. Opioid drugs can put you at risk for addiction, abuse, and misuse. Misuse or abuse of EndaCof-C (codeine and chlorpheniramine liquid) can lead to overdose and death. If you have questions, talk with your doctor.
  • This medicine has an opioid drug in it. The use of opioid drugs along with a benzodiazepine drug or other drugs that may make you drowsy or slow your actions has led to very bad side effects. Side effects that have happened include slowed or trouble breathing and deaths. Benzodiazepine drugs include drugs like alprazolam, diazepam, and lorazepam. Benzodiazepine drugs are used to treat many health problems like anxiety, trouble sleeping, or seizures. Talk with the doctor.
  • Many drugs interact with EndaCof-C (codeine and chlorpheniramine liquid) and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use EndaCof-C (codeine and chlorpheniramine liquid) with all of your drugs.
  • Avoid alcohol or other drugs and natural products that slow your actions.
  • Get medical help right away if you feel very sleepy, very dizzy, or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
  • Very bad and sometimes deadly breathing problems have happened with EndaCof-C (codeine and chlorpheniramine liquid). Talk with the doctor.
  • Get medical help right away if you have slow breathing, shallow breathing, or trouble breathing.
Children:
  • This medicine is not for use in children younger than 18 years of age. The benefits of taking EndaCof-C (codeine and chlorpheniramine liquid) for a cough due to allergies, a cold, or other infection do not outweigh the risks in children. If your child has been given EndaCof-C (codeine and chlorpheniramine liquid) or if you have any questions, talk with your child's doctor.

Uses of EndaCof-C:

  • It is used to ease allergy signs.
  • It is used to relieve coughing.

What do I need to tell my doctor BEFORE I take EndaCof-C?

  • If you have an allergy to EndaCof-C (codeine and chlorpheniramine liquid) or any part of EndaCof-C (codeine and chlorpheniramine liquid).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have had a recent head injury, brain injury or tumor, or raised pressure in the brain.
  • If you have a cough with a lot of mucous.
  • If you have a long-term cough caused by smoking or being around smoke, or lung problems like asthma or emphysema.
  • If you have any of these health problems: Lung or breathing problems like asthma, trouble breathing, or sleep apnea; high levels of carbon dioxide in the blood; or stomach or bowel block or narrowing.
  • If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking EndaCof-C (codeine and chlorpheniramine liquid) within 14 days of those drugs can cause very bad high blood pressure.
  • If you are taking any of these drugs: Linezolid or methylene blue.
  • If you are taking any of these drugs: Buprenorphine, butorphanol, nalbuphine, or pentazocine.
  • If you are breast-feeding. Do not breast-feed while you take EndaCof-C (codeine and chlorpheniramine liquid).

This is not a list of all drugs or health problems that interact with EndaCof-C (codeine and chlorpheniramine liquid).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take EndaCof-C (codeine and chlorpheniramine liquid) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take EndaCof-C?

  • Tell all of your health care providers that you take EndaCof-C (codeine and chlorpheniramine liquid). This includes your doctors, nurses, pharmacists, and dentists.
  • Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
  • Do not take EndaCof-C (codeine and chlorpheniramine liquid) for longer than you were told by your doctor.
  • Avoid driving and doing other tasks or actions that call for alertness while you take EndaCof-C (codeine and chlorpheniramine liquid). Talk with your doctor.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
  • This medicine may be habit-forming with long-term use.
  • If you have been taking EndaCof-C (codeine and chlorpheniramine liquid) on a regular basis and you stop it all of a sudden, you may have signs of withdrawal. Do not stop taking EndaCof-C (codeine and chlorpheniramine liquid) all of a sudden without calling your doctor. Tell your doctor if you have any bad effects.
  • Do not take EndaCof-C (codeine and chlorpheniramine liquid) with other strong pain drugs or if you are using a pain patch without talking to your doctor first.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take EndaCof-C (codeine and chlorpheniramine liquid).
  • Keep away from children. Accidental exposure may cause death. If a child takes EndaCof-C (codeine and chlorpheniramine liquid) by accident, get medical help right away.
  • If you are 65 or older, use EndaCof-C (codeine and chlorpheniramine liquid) with care. You could have more side effects.
  • The chance of very bad side effects may be higher in children. This may be more likely to happen in children who have breathing problems. Deadly breathing problems have happened with the use of codeine in some children. Talk with the doctor.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking EndaCof-C (codeine and chlorpheniramine liquid), call your doctor right away.
  • Using EndaCof-C (codeine and chlorpheniramine liquid) for a long time during pregnancy may lead to withdrawal in the newborn baby. This can be life-threatening. Talk with the doctor.

How is this medicine (EndaCof-C) best taken?

Use EndaCof-C (codeine and chlorpheniramine liquid) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food. Take with food if it causes an upset stomach.
  • Measure liquid doses carefully. Use the measuring device that comes with EndaCof-C (codeine and chlorpheniramine liquid). If there is none, ask the pharmacist for a device to measure EndaCof-C (codeine and chlorpheniramine liquid).
  • Do not mix with other liquids.

What do I do if I miss a dose?

  • If you take EndaCof-C (codeine and chlorpheniramine liquid) on a regular basis, take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • Many times EndaCof-C (codeine and chlorpheniramine liquid) is taken on an as needed basis. Do not take more often than told by the doctor.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high or low blood pressure like very bad headache or dizziness, passing out, change in eyesight.
  • Chest pain or pressure or a fast heartbeat.
  • Noisy breathing.
  • Feeling very sleepy.
  • Feeling very tired or weak.
  • Feeling confused.
  • Slow heartbeat.
  • A heartbeat that does not feel normal.
  • Hallucinations (seeing or hearing things that are not there).
  • Low mood (depression).
  • Mood changes.
  • Seizures.
  • Trouble passing urine.
  • Shakiness.
  • Change in eyesight.
  • Very upset stomach or throwing up.
  • Very hard stools (constipation).
  • Very bad belly pain.
  • Trouble controlling body movements.
  • Feeling agitated.
  • Restlessness.
  • This medicine may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing.

What are some other side effects of EndaCof-C?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling sleepy.
  • Feeling nervous and excitable.
  • Not able to sleep.
  • Hard stools (constipation).
  • Dizziness.
  • Upset stomach or throwing up.
  • Sweating a lot.
  • Feeling tired or weak.
  • Headache.
  • Belly pain.
  • Bloating.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out EndaCof-C?

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time EndaCof-C (codeine and chlorpheniramine liquid) is refilled. If you have any questions about EndaCof-C (codeine and chlorpheniramine liquid), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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