Generic Name: methadone (METH-a-done)
Brand Name: Generic only. No brands available.
Dolophine solution is a narcotic medicine that may become habit-forming. Misuse or abuse can lead to overdose and death. Do NOT take more than the recommended dose, take for longer than prescribed, or take more often than prescribed without checking with your doctor.
Dolophine solution may cause severe and sometimes fatal breathing problems. This effect may occur at any time after you take a dose. The risk may be greater when you first start this drug or with any increase in dose. Contact your doctor right away if you experience slow, shallow, or difficult breathing.
Dolophine solution is for injection only. Accidental swallowing of Dolophine solution may be fatal, especially in children. Keep Dolophine solution out of the reach of children. Seek emergency medical care right away if Dolophine solution is swallowed.
Certain types of severe and sometimes fatal irregular heartbeat (QT prolongation, torsades de pointes) have occurred in patients taking Dolophine solution. Tell your doctor right away if you develop an irregular heartbeat.
Long-term use of Dolophine solution during pregnancy may cause dependence in the unborn baby. This can lead to withdrawal in the newborn, which can be life-threatening. Discuss any questions or concerns with your doctor.
If Dolophine solution is used to treat narcotic (opioid) addiction, it can only be dispensed through a special program. Contact your doctor for instructions.
Dolophine solution is used for:
Treating moderate to severe pain that is not relieved by other pain medicines. It is also used in the temporary treatment of narcotic (opioid) addiction as part of a treatment program in patients who are unable to take medicine by mouth. It may also be used for other conditions as determined by your doctor.
Dolophine solution is a narcotic (opioid) medicine. It works by acting in the brain and nervous system.
Do NOT use Dolophine solution if:
- you are allergic to any ingredient in Dolophine solution
- you have slow, shallow, or difficult breathing
- you have high levels of carbon dioxide in the blood (hypercapnia or hypercarbia) or severe lung problems (eg, severe asthma), or you are having an asthma attack
- you have narrowing of the stomach or bowels or known or suspected stomach or bowel blockage (eg, paralytic ileus)
- you are taking asenapine, buprenorphine, a mixed agonist/antagonist pain medicine (eg, butorphanol, nalbuphine, pentazocine), nilotinib, tetrabenazine, or sodium oxybate (GHB)
- you are taking a monamine oxidase inhibitor (MAOI) (eg, phenelzine, selegiline) or you have taken one within the last 14 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using Dolophine solution:
Some medical conditions may interact with Dolophine solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have allergies to medicines, especially any narcotic pain medicines (eg, codeine, hydromorphone); foods; or other substances
- if you have a history of chronic obstructive pulmonary disease (COPD) or other lung or breathing problems (eg, asthma, bronchitis, emphysema), sleep apnea, curvature of the spine (scoliosis), high levels of blood carbon dioxide in the blood, or low levels of oxygen in the blood (hypoxia)
- if you have severe drowsiness, increased pressure in the brain, a recent head injury, growths in the brain (eg, tumors, lesions), or a history of seizures (eg, epilepsy)
- if you have a history of liver or kidney problems, thyroid problems, stomach or bowel problems (eg, blockage, inflammation), gallbladder problems, pancreas problems (eg, pancreatitis), heart problems (eg, cor pulmonale; enlarged heart; fast, slow, or irregular heartbeat), adrenal gland problems (eg, Addison disease), an enlarged prostate, or urinary blockage or trouble urinating
- if you have low blood pressure, dehydration, low blood volume, constipation, stomach pain, low blood potassium or magnesium levels, or poor health
- if you drink alcohol, have symptoms of alcohol withdrawal, or have a history of suicidal thoughts or attempts
- if you or a family member have a history of mental or mood problems (eg, anxiety, depression), or alcohol or other substance abuse or dependence
- if you are very overweight, or have recently had or will be having surgery (eg, stomach or bowel surgery)
- If you are taking a benzodiazepine (eg, alprazolam). Deaths have happened when Dolophine solution was abused by people taking a benzodiazepine
- if you have never taken a narcotic pain medicine before
- if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat
Some MEDICINES MAY INTERACT with Dolophine solution. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Many prescription and nonprescription medicines (eg, used for alcohol or other substance abuse or dependence, cancer, constipation, depression or other mental or mood problems, hepatitis C, high blood pressure, HIV, Huntington disease, infections, immune system suppression, irregular heartbeat or other heart problems, nausea or vomiting, pain, Parkinson disease, reflux or other stomach problems, seizures, sleeping problems, Tourette syndrome), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) because they may interact with Dolophine solution. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with Dolophine solution
This may not be a complete list of all interactions that may occur. Ask your health care provider if Dolophine solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Dolophine solution:
Use Dolophine solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Dolophine solution is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
- Dolophine solution must be administered under close medical supervision.
- Do not suddenly stop taking Dolophine solution. You may have an increased risk of withdrawal symptoms (eg, nausea, vomiting, diarrhea, anxiety, shivering). If you need to stop Dolophine solution, your doctor will gradually lower your dose.
- If you miss a dose of Dolophine solution and:
- You are taking it for pain, take it as soon as possible then take your next dose as directed by your doctor. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Do not take more than your prescribed dose in 24 hours.
- You are taking it for narcotic (opioid) addiction, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Do not take more than your prescribed dose in 24 hours.
Ask your health care provider any questions you may have about how to use Dolophine solution.
Important safety information:
- Tell your doctor or dentist that you take Dolophine solution before you receive any medical or dental care, emergency care, or surgery.
- Dolophine solution may cause drowsiness, dizziness, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Dolophine solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol or take medicines (prescription or nonprescription) that have alcohol in them while you are taking Dolophine solution. Ask your pharmacist if you have questions about if any of your medicines have alcohol in them.
- Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Dolophine solution; the risk of severe drowsiness or breathing problems may be increased. Ask your pharmacist if you have questions about which medicines may increase the risk of these effects.
- Dolophine solution may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Dolophine solution may cause constipation. Talk with your doctor or pharmacist about using a stool softener or laxative to prevent constipation. It is also important to maintain a diet adequate in fiber, drink plenty of water, and exercise to prevent constipation. If you become constipated while taking Dolophine solution, talk with your doctor or pharmacist.
- Do NOT take more than the recommended dose, take Dolophine solution for longer than prescribed, or take more often than prescribed without talking with your doctor.
- If you have side effects that concern you, contact your doctor. If you are taking Dolophine solution for pain, contact your doctor if your pain continues or becomes worse.
- Seek emergency medical care right away if Dolophine solution is swallowed. Accidental swallowing of Dolophine solution may be fatal, especially in children.
- Use Dolophine solution with caution in the ELDERLY; they may be more sensitive to its effects, especially breathing problems.
- PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Dolophine solution while you are pregnant. Long-term use of Dolophine solution during pregnancy may cause dependence in the fetus or newborn. Discuss any questions or concerns with your doctor. Dolophine solution is found in breast milk. If you are or will be breast-feeding while you use Dolophine solution, check with your doctor. Discuss any possible risks to your baby.
When used for long periods of time or at high dose, Dolophine solution may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Dolophine solution stops working well. Do not take more than prescribed.
Some people who use Dolophine solution for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.
If you stop taking Dolophine solution suddenly, you may have WITHDRAWAL symptoms. These may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.
Possible side effects of Dolophine solution:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; dizziness; drowsiness; headache; light-headedness; nausea; pain, redness, or swelling at the injection site; sweating; tiredness; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); abnormal sighing; chest pain; confusion; decreased sexual desire or ability; fainting; fast, slow, or irregular heartbeat; hallucinations; menstrual changes; mental or mood changes (eg, agitation, depression); muscle pain, weakness, or cramping; seizures; severe or persistent constipation or stomach pain; severe or persistent dizziness, drowsiness, headache, or light-headedness; severe or persistent pain, redness, or swelling at the injection site; shortness of breath; slow, difficult, or shallow breathing; sudden, unexplained weight gain; swelling of the arms, feet, or legs; trouble sleeping; trouble urinating; unusual bruising or bleeding; unusual tiredness or weakness; vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Dolophine solution is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.
- If you have any questions about Dolophine solution, please talk with your doctor, pharmacist, or other health care provider.
- Dolophine solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Dolophine solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Dolophine solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Dolophine solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Dolophine solution.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.