Generic Name: dolasetron (doe-LAS-e-tron)
Brand Name: Anzemet
Dolasetron tablets are used for:
Preventing nausea and vomiting associated with cancer chemotherapy. It may also be used to prevent nausea and vomiting after surgery.
Dolasetron tablets are a serotonin 5-HT3 receptor blocker. It works by blocking a substance thought to be a cause of nausea and vomiting in certain situations.
Do NOT use dolasetron tablets if:
- you are allergic to any ingredient in dolasetron tablets
- you have a certain type of irregular heartbeat (congenital long QT syndrome), or uncorrected low blood potassium or magnesium levels
- you have or are at risk of complete heart block and do not have a pacemaker
- you are taking apomorphine or nilotinib
Contact your doctor or health care provider right away if any of these apply to you.
Before using dolasetron tablets:
Some medical conditions may interact with dolasetron tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of heart problems (eg, slow or irregular heartbeat, sick sinus syndrome, heart attack, heart failure), kidney problems, or low potassium or magnesium levels in the blood
- if you are taking medicines that may cause a certain type of irregular heartbeat (eg, flecainide, verapamil, quinidine)
Some MEDICINES MAY INTERACT with dolasetron tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Anthracyclines (eg, doxorubicin), antiarrhythmics (eg, amiodarone, dofetilide, sotalol), arsenic, astemizole, bepridil, chloroquine, cimetidine, cisapride, diuretics (eg, furosemide), domperidone, droperidol, halofantrine, haloperidol, histone deacetylase inhibitors (eg, romidepsin), iloperidone, ketolides (eg, telithromycin), macrolides (eg, erythromycin), maprotiline, methadone, nilotinib, paliperidone, pentamidine, phenothiazines (eg, thioridazine), pimozide, quinolones (eg, levofloxacin), streptogramins (eg, quinupristin/dalfopristin), terfenadine, tetrabenazine, tricyclic antidepressants (eg, nortriptyline), tyrosine kinase inhibitors (eg, sunitinib), or ziprasidone because the risk of irregular heart rhythm is increased
- Apomorphine because the risk of severe low blood pressure or loss of consciousness may be increased
- Rifampin because it may decrease dolasetron tablets's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if dolasetron tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use dolasetron tablets:
Use dolasetron tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take dolasetron tablets by mouth with or without food.
- Take your dose of dolasetron tablets as directed before the start of your cancer treatment or surgery.
- Swallow dolasetron tablets whole. Do not break, crush, or chew before swallowing. Crushing or chewing the tablets may lead to increased side effects or decreased effectiveness, and the tablets will have a bitter, unpleasant taste.
- If you miss a dose of dolasetron tablets, contact your doctor right away.
Ask your health care provider any questions you may have about how to use dolasetron tablets.
Important safety information:
- Dolasetron tablets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use dolasetron tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Dolasetron tablets may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Do NOT take more than the recommended dose of dolasetron tablets without checking with your doctor.
- If you are taking dolasetron tablets to prevent nausea and vomiting associated with cancer chemotherapy, take dolasetron tablets only on the days that you take your cancer treatment unless otherwise directed by your doctor. If you continue to experience moderate to severe vomiting while taking dolasetron tablets, check with your doctor.
- Dolasetron tablets may cause severe and sometimes fatal irregular heartbeats. Discuss any questions or concerns with your doctor.
- Serotonin syndrome is a possibly fatal syndrome that can be caused by dolasetron tablets. Your risk may be greater if you take dolasetron tablets with certain other medicines (eg, certain medicines used to treat depression, pain, migraines). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
- Tell your doctor or dentist that you take dolasetron tablets before you receive any medical or dental care, emergency care, or surgery.
- Lab tests, including electrocardiograms (ECGs) and blood potassium or magnesium levels, may be performed while you use dolasetron tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use dolasetron tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially irregular heartbeat.
- Do not give dolasetron tablets to CHILDREN who are unable to swallow tablets.
- Dolasetron tablets should be used with extreme caution in CHILDREN younger than 2 years; safety and effectiveness in these children have not been confirmed.
- Caution is advised when using dolasetron tablets in CHILDREN; they may be more sensitive to its effects.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using dolasetron tablets while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use dolasetron tablets, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of dolasetron tablets:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Chills; diarrhea; dizziness; headache; indigestion; tiredness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in heartbeat (including fast, slow, or irregular heartbeat); chest pain; fainting; lightheadedness; numbness or pain of an arm or leg; pounding in the chest; shortness of breath; sudden, severe headache, stomach pain, dizziness, or vomiting; sudden vision changes; urination problems.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of dolasetron tablets:
Store dolasetron tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep dolasetron tablets out of the reach of children and away from pets.
- If you have any questions about dolasetron tablets, please talk with your doctor, pharmacist, or other health care provider.
- Dolasetron tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take dolasetron tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about dolasetron tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to dolasetron tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using dolasetron tablets.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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