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DDAVP Nasal Spray (Diabetes Insipidus)

Generic Name: Desmopressin Nasal Spray (Diabetes Insipidus) (des moe PRES in)
Brand Name: DDAVP, DDAVP Rhinal Tube

Medically reviewed on Sep 5, 2018

Uses of DDAVP:

  • It is used to treat diabetes insipidus.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take DDAVP?

  • If you have an allergy to DDAVP (desmopressin nasal spray (diabetes insipidus)) or any part of DDAVP (desmopressin nasal spray (diabetes insipidus)).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Kidney disease or if you have ever had low sodium levels.
  • If you have any of these health problems: Heart failure (weak heart), high blood pressure, or a health problem called syndrome of inappropriate antidiuretic hormone (SIADH) secretion.
  • If you have type IIB von Willebrand disease.
  • If you have a health problem that leads to sodium loss like adrenal gland problems, diarrhea, eating disorders like anorexia or bulimia, nausea, or vomiting that will not stop.
  • If you are drinking more water than normal.
  • If you are pregnant or plan to get pregnant.
  • If you have a stuffy nose, scarring on the inside of your nose, or you have trouble breathing through your nose.
  • If you have had any recent nose surgery, injury, ulcers, or sores, talk with your doctor.
  • If you are using another drug in the nose.

This is not a list of all drugs or health problems that interact with DDAVP (desmopressin nasal spray (diabetes insipidus)).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take DDAVP (desmopressin nasal spray (diabetes insipidus)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take DDAVP?

  • Tell all of your health care providers that you take DDAVP (desmopressin nasal spray (diabetes insipidus)). This includes your doctors, nurses, pharmacists, and dentists.
  • Very bad allergic reactions have rarely happened. Sometimes, allergic reactions have been deadly with the shot form of DDAVP (desmopressin nasal spray (diabetes insipidus)). Talk with the doctor.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
  • Use with care in children. Talk with the doctor.

How is this medicine (DDAVP) best taken?

Use DDAVP (desmopressin nasal spray (diabetes insipidus)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • You may need to watch how much fluid you drink while taking DDAVP (desmopressin nasal spray (diabetes insipidus)). Follow what your doctor has told you about how much fluid you can drink and how much physical activity you can have. If you have questions, talk with your doctor.
  • Follow how to use as you have been told by the doctor or read the package insert.
  • Do not take DDAVP (desmopressin nasal spray (diabetes insipidus)) by mouth. Use in your nose only. Keep out of your mouth and eyes (may burn).
  • Blow your nose before use.
  • Some products may have different ways to prime the pump. Some pumps may also need to be primed if not used for different periods of time. Follow how and when to prime as you have been told.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low sodium levels like headache, trouble focusing, memory problems, feeling confused, weakness, seizures, or change in balance.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Upset stomach or throwing up.
  • Hallucinations (seeing or hearing things that are not there).
  • Feeling tired or weak.
  • Restlessness.
  • Muscle weakness.
  • Muscle spasm.
  • Not hungry.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Chest pain or pressure or a fast heartbeat.
  • Coughing up blood.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • A heartbeat that does not feel normal.

What are some other side effects of DDAVP?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out DDAVP?

  • Some brands of DDAVP (desmopressin nasal spray (diabetes insipidus)) need to be stored in a refrigerator. Some brands of DDAVP (desmopressin nasal spray (diabetes insipidus)) need to be stored at room temperature. If you have questions about how to store DDAVP (desmopressin nasal spray (diabetes insipidus)), talk with your pharmacist.
  • Be sure you know how long you can store DDAVP (desmopressin nasal spray (diabetes insipidus)) before you need to throw it away.
  • Store upright with the cap on.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about DDAVP (desmopressin nasal spray (diabetes insipidus)), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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