Skip to Content

Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide

Generic Name: Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide (dar UE na vir, koe BIK i stat, EM trye SYE ta been, and ten OF oh vir AL a FEN a mide)
Brand Name: Symtuza

Medically reviewed by Drugs.com. Last updated on May 31, 2019.

Warning

  • Hepatitis B has gotten worse when darunavir, cobicistat, emtricitabine, and tenofovir alafenamide was stopped in some people with hepatitis B. Close follow-up for a few months is needed when therapy is stopped in people who have hepatitis B. Do not stop taking darunavir, cobicistat, emtricitabine, and tenofovir alafenamide without calling your doctor.
  • This medicine is not approved to treat hepatitis B. Hepatitis B testing needs to be done before taking darunavir, cobicistat, emtricitabine, and tenofovir alafenamide.

Uses of Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide:

What do I need to tell my doctor BEFORE I take Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide?

  • If you have an allergy to darunavir, cobicistat, emtricitabine, and tenofovir alafenamide or any part of darunavir, cobicistat, emtricitabine, and tenofovir alafenamide.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Kidney disease or liver disease.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with darunavir, cobicistat, emtricitabine, and tenofovir alafenamide, like certain drugs that are used for high cholesterol, migraines, or mood problems. There are many drugs that must not be taken with darunavir, cobicistat, emtricitabine, and tenofovir alafenamide.
  • If you are taking St. John's wort. Do not take St. John's wort with darunavir, cobicistat, emtricitabine, and tenofovir alafenamide. This medicine may not work as well.
  • If you are taking any other drugs to treat HIV.
  • If you are taking any drugs that can raise the chance of kidney problems. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
  • If you are pregnant or may be pregnant. Do not take darunavir, cobicistat, emtricitabine, and tenofovir alafenamide if you are pregnant.
  • If you are breast-feeding. Do not breast-feed while you take darunavir, cobicistat, emtricitabine, and tenofovir alafenamide.

This is not a list of all drugs or health problems that interact with darunavir, cobicistat, emtricitabine, and tenofovir alafenamide.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take darunavir, cobicistat, emtricitabine, and tenofovir alafenamide with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide?

  • Tell all of your health care providers that you take darunavir, cobicistat, emtricitabine, and tenofovir alafenamide. This includes your doctors, nurses, pharmacists, and dentists.
  • If you have a sulfa (sulfonamide) allergy, talk with your doctor.
  • This medicine interacts with many other drugs. The chance of darunavir, cobicistat, emtricitabine, and tenofovir alafenamide's side effects may be raised or how well darunavir, cobicistat, emtricitabine, and tenofovir alafenamide works may be lowered. The chance of the other drugs' side effects may also be raised. This may include very bad, life-threatening, or deadly side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take darunavir, cobicistat, emtricitabine, and tenofovir alafenamide with all of your other drugs (prescription or OTC, natural products, vitamins).
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • High blood sugar has happened with darunavir, cobicistat, emtricitabine, and tenofovir alafenamide. This includes diabetes that is new or worse. Talk with the doctor.
  • Check your blood sugar as you have been told by your doctor.
  • This medicine may cause high cholesterol and triglyceride levels. Talk with the doctor.
  • Some people with hemophilia have had times of more bleeding when taking drugs like this one. If you have hemophilia, talk with your doctor.
  • Kidney problems like kidney failure have happened with darunavir, cobicistat, emtricitabine, and tenofovir alafenamide. Tell your doctor if you have ever had kidney problems.
  • This medicine is not a cure for HIV. Stay under the care of your doctor.
  • This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors.
  • This medicine may rarely cause swollen liver and an acid health problem in the blood. This may be deadly in some cases. The chance may be higher in women, in overweight people, and in people who have taken drugs like this one for a long time. Talk with your doctor.
  • Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking darunavir, cobicistat, emtricitabine, and tenofovir alafenamide.

How is this medicine (Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide) best taken?

Use darunavir, cobicistat, emtricitabine, and tenofovir alafenamide as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take darunavir, cobicistat, emtricitabine, and tenofovir alafenamide with food.
  • Some products may be broken in half. If you are not sure if you can break this product in half, talk with the doctor.
  • Take darunavir, cobicistat, emtricitabine, and tenofovir alafenamide at the same time of day.
  • Keep taking darunavir, cobicistat, emtricitabine, and tenofovir alafenamide as you have been told by your doctor or other health care provider, even if you feel well.
  • It is important that you do not miss or skip a dose of darunavir, cobicistat, emtricitabine, and tenofovir alafenamide during treatment.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it, with food.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • If you are not sure what to do if you miss a dose, call your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of too much lactic acid in the blood (lactic acidosis) like fast breathing, fast heartbeat, a heartbeat that does not feel normal, very bad upset stomach or throwing up, feeling very sleepy, shortness of breath, feeling very tired or weak, very bad dizziness, feeling cold, or muscle pain or cramps.
  • Muscle or joint pain.
  • Feeling very tired or weak.
  • Changes in your immune system can happen when you start taking drugs to treat HIV. If you have an infection that you did not know you had, it may show up when you take darunavir, cobicistat, emtricitabine, and tenofovir alafenamide. Tell your doctor right away if you have any new signs after you start darunavir, cobicistat, emtricitabine, and tenofovir alafenamide, even after taking it for several months. This includes signs of infection like fever, sore throat, weakness, cough, or shortness of breath.
  • Liver problems have rarely happened with darunavir, cobicistat, emtricitabine, and tenofovir alafenamide. Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide?

  • Store at room temperature.
  • Store in the original container. Do not take out the antimoisture cube or packet.
  • Keep lid tightly closed.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about darunavir, cobicistat, emtricitabine, and tenofovir alafenamide, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Related questions

Hide