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Cyclopentolate and Phenylephrine

Generic Name: Cyclopentolate and Phenylephrine (sye kloe PEN toe late & fen il EF rin)
Brand Name: Cyclomydril

Medically reviewed by Last updated on Jul 25, 2020.

Uses of Cyclopentolate and Phenylephrine:

  • It makes the eye pupils larger.

What do I need to tell my doctor BEFORE I take Cyclopentolate and Phenylephrine?

This is not a list of all drugs or health problems that interact with cyclopentolate and phenylephrine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take cyclopentolate and phenylephrine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Cyclopentolate and Phenylephrine?

For all patients taking cyclopentolate and phenylephrine:

  • Tell all of your health care providers that you take cyclopentolate and phenylephrine. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for clear eyesight while your pupils are dilated.
  • Bright lights may bother you. Wear sunglasses.
  • Use cyclopentolate and phenylephrine with care in children. They may have more side effects. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using cyclopentolate and phenylephrine while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.


  • Watch infants closely for at least 30 minutes after giving cyclopentolate and phenylephrine.
  • If cyclopentolate and phenylephrine is used on an infant, do not feed the infant until 4 hours after the exam is over.

How is this medicine (Cyclopentolate and Phenylephrine) best taken?

Use cyclopentolate and phenylephrine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • For the eye only.
  • Your doctor will give cyclopentolate and phenylephrine.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Change in eyesight, eye pain, or very bad eye irritation.
  • A fast heartbeat.
  • Fever.
  • Very bad headache.
  • Flushing.
  • Trouble passing urine.
  • Feeling confused.
  • Hallucinations (seeing or hearing things that are not there).
  • Seizures.
  • Change in balance.
  • Trouble walking.
  • Slurred speech.
  • Restlessness.

What are some other side effects of Cyclopentolate and Phenylephrine?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Eye irritation.
  • Burning.
  • Blurred eyesight.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Cyclopentolate and Phenylephrine?

  • If you need to store cyclopentolate and phenylephrine at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about cyclopentolate and phenylephrine, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about cyclopentolate / phenylephrine ophthalmic

Consumer resources

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