Generic Name: rosuvastatin (roe-SOO-va-STAT-in)
Brand Name: Crestor
Crestor is used for:
Lowering high cholesterol and triglycerides in certain patients. It also increases high-density lipoprotein (HDL) ("good") cholesterol levels. It is used to slow atherosclerosis (narrowing of the arteries) in patients with high blood cholesterol levels. It is used in certain patients to reduce the risk of heart attack or stroke. It is also used in certain patients to reduce the need for medical procedures to open blocked heart vessels. It is used along with an appropriate diet. It may also be used for other conditions as determined by your doctor.
Crestor is an HMG-CoA reductase inhibitor, also known as a "statin." It works by reducing the production of certain fatty substances in the body, including cholesterol.
Do NOT use Crestor if:
- you are allergic to any ingredient in Crestor
- you have active liver disease or unexplained abnormal liver function tests
- you are pregnant, think you may be pregnant, may become pregnant, or are breast-feeding
Contact your doctor or health care provider right away if any of these apply to you.
Before using Crestor:
Some medical conditions may interact with Crestor. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, if you are planning to become pregnant, or are breast-feeding
- if you are able to become pregnant
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of muscle problems (eg, pain, weakness), including muscle problems with the use of another statin (eg, simvastatin) or a family history of hereditary muscle problems
- if you have low blood pressure, a serious infection, kidney problems, liver problems, thyroid problems, diabetes or high blood sugar levels, or a history of seizures
- if you are dehydrated; have increased creatine phosphokinase (CPK) blood levels; or have metabolism, hormonal, or electrolyte problems
- if you are on dialysis
- if you drink alcohol or have a history of alcohol abuse
- if you have had an organ transplant or have recently had major surgery or a serious injury
- if you do excessive physical exercise
Some MEDICINES MAY INTERACT with Crestor. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Colchicine, cyclosporine, daptomycin, fibrates (eg, clofibrate, fenofibrate, gemfibrozil), HIV protease inhibitors (eg, atazanavir, lopinavir, ritonavir), or niacin because they may increase the risk of muscle or kidney problems
- Dronedarone, eltrombopag, or itraconazole because they may increase the risk of Crestor's side effects
- Anticoagulants (eg, warfarin), cimetidine, ketoconazole, sirolimus, spironolactone, or tacrolimus because the risk of their side effects may be increased by Crestor
This may not be a complete list of all interactions that may occur. Ask your health care provider if Crestor may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Crestor:
Use Crestor as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Crestor. Talk to your pharmacist if you have questions about this information.
- Take Crestor by mouth with or without food.
- Swallow the tablets whole.
- If you also take an antacid that has aluminum or magnesium in it, take it at least 2 hours after taking Crestor. Check with your doctor if you have any questions.
- Taking Crestor at the same time each day will help you remember to take it.
- Continue to take Crestor even if you feel well. Do not miss any doses.
- If you miss a dose of Crestor, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once or within 12 hours of each other.
Ask your health care provider any questions you may have about how to use Crestor.
Important safety information:
- Crestor may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Crestor with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Crestor may cause liver problems. Rarely, severe and sometimes fatal liver failure has been reported in patients taking Crestor. Your risk of developing liver problems may be greater if you drink alcohol daily or in large amounts with Crestor, or if you have a history of liver problems. Check with your doctor before drinking alcohol while you are taking Crestor. Tell your doctor right away if you experience symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent nausea, loss of appetite, or stomach pain; unusual tiredness).
- Follow the diet and exercise program given to you by your health care provider.
- Tell your doctor or dentist that you take Crestor before you receive any medical or dental care, emergency care, or surgery.
- Women who may become pregnant should use effective birth control while taking Crestor. Check with your doctor if you have questions about using birth control.
- Do NOT take more than the recommended dose without checking with your doctor.
- Muscle problems (myopathy) may occur with Crestor. The risk of muscle problems may be greater in people who take higher doses of Crestor, in people 65 years old and older, or in people who have liver or kidney problems or low thyroid function. It may also be greater in those who take it with certain other medicines (eg, niacin). Report any unexplained muscle pain, tenderness, or weakness to your doctor right away, especially if you also have a fever or general body discomfort or if you have muscle problems that persist even after your doctor has told you to stop taking Crestor.
- Diabetes patients - Crestor may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Lab tests, including blood cholesterol levels, liver function, kidney function, and CPK blood levels, may be performed while you use Crestor. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Crestor with caution in ASIAN patients and in the ELDERLY; they may be more sensitive to its effects, especially serious muscle problems (eg, muscle pain, tenderness, or weakness).
- Crestor should be used with extreme caution in CHILDREN younger than 10 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Do not use Crestor if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Crestor.
Possible side effects of Crestor:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; headache; nausea; stomach pain; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or dark urine; change in the amount of urine produced; chest pain; confusion; depression; joint pain; memory problems (eg, forgetfulness, memory loss); muscle pain, tenderness, or weakness (with or without fever or fatigue); red, swollen, blistered, or peeling skin; severe or persistent headache; severe or persistent nausea or vomiting; severe stomach or back pain (with or without nausea or vomiting); swelling of the hands, ankles, or feet; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools, loss of appetite, unusual tiredness); trouble sleeping.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Crestor:
Store Crestor at room temperature, between 68 and 77 degrees F (20 to 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Crestor out of the reach of children and away from pets.
- If you have any questions about Crestor, please talk with your doctor, pharmacist, or other health care provider.
- Crestor is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Crestor or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Crestor. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Crestor. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Crestor.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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- Drug class: statins