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Generic Name: prochlorperazine (pro-klor-PURR-uh-zeen)
Brand Name: Compazine
Compazine syrup is used for:
Controlling severe nausea and vomiting and treating schizophrenia. It is also used for the short-term (4 weeks) treatment of generalized nonpsychotic anxiety. It may also be used for other conditions as determined by your doctor.
Compazine syrup is a phenothiazine. It works by blocking a certain chemical (dopamine) in the brain.
Do NOT use Compazine syrup if:
- you are allergic to any ingredient in Compazine syrup or similar medicines
- you are taking astemizole, cisapride, or terfenadine
- you have severe central nervous system depression
Contact your doctor or health care provider right away if any of these apply to you.
Before using Compazine syrup:
Some medical conditions may interact with Compazine syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of heart disease, central nervous system depression, blood problems, liver problems, low blood pressure, increased pressure in the eye, neuroleptic malignant syndrome, tardive dyskinesia, bone marrow problems, unusual muscle movements, Parkinson disease, a predisposition to glaucoma, Reye syndrome, prostate problems, or seizures, or you have alcoholism
Some MEDICINES MAY INTERACT with Compazine syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine) or lithium because they may decrease Compazine syrup's effectiveness
- Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine), general anesthetics (eg, thiopental), haloperidol, methyldopa, or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects, such as seizures, may be increased
- ACE inhibitors (eg, enalapril), anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine), astemizole, cisapride, dofetilide, haloperidol, hydantoins (eg, phenytoin), methyldopa, metrizamide, naltrexone, polypeptide antibiotics (eg, actinomycin), serotonin receptor antagonist antiemetics (eg, ondansetron), terfenadine, tramadol, trazodone, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Compazine syrup
- Bromocriptine, guanethidine, levodopa, or pergolide because their effectiveness may be decreased by Compazine syrup
- Lithium because unexpected toxic effects may occur
This may not be a complete list of all interactions that may occur. Ask your health care provider if Compazine syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Compazine syrup:
Use Compazine syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Compazine syrup by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- If you miss a dose of Compazine syrup, take it as soon as possible. If you are taking 1 dose at bedtime and do not remember until the next morning, skip the missed dose and go back to your regular dosing schedule.
Ask your health care provider any questions you may have about how to use Compazine syrup.
Important safety information:
- Compazine syrup may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Compazine syrup with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Compazine syrup may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Compazine syrup; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Tell your doctor or dentist that you take Compazine syrup before you receive any medical or dental care, emergency care, or surgery.
- Compazine syrup may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Compazine syrup. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Avoid exposure to extreme heat while taking Compazine syrup.
- Patients who will be having spinal cord surgery should stop using Compazine syrup at least 48 hours before surgery. Do not use Compazine syrup for at least 24 hours after surgery and do not use it to control nausea and vomiting that has occurred before or after surgery.
- Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Compazine syrup. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
- Use Compazine syrup with caution in the ELDERLY; they may be more sensitive to its effects.
- Compazine syrup should not be used in CHILDREN who are having surgery, who are younger than 2 years old, or who weigh less than 20 pounds; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Compazine syrup while you are pregnant. Compazine syrup is found in breast milk. If you are or will be breast-feeding while you use Compazine syrup, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Compazine syrup:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Blurred vision; chills; constipation; dizziness; drowsiness; dry mouth; jitteriness; nasal congestion; sleeplessness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; altered mental abilities, including lack of response to your surroundings; changes in breasts; changes in menstrual period; changes in vision; difficulty swallowing; drooling; excessive sweating; fever; inability to move eyes; increased body heat; involuntary movements of tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements); irregular or fast heartbeat; mask-like face; muscle stiffness; muscle spasms of face, neck, or back; prolonged or painful erection; restlessness; rigid muscles; shuffling walk; sore throat; tension in legs; tremors; twitching or twisting movements; unusual eye movements; weakness of arms or legs; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; muscle spasms; restlessness; seizures; tremors; twitching.Proper storage of Compazine syrup:
Store Compazine syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Compazine syrup out of the reach of children and away from pets.
- If you have any questions about Compazine syrup, please talk with your doctor, pharmacist, or other health care provider.
- Compazine syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Compazine syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.