Generic name: Cladribine Tablets (KLA dri been)
Brand name: Mavenclad
Drug class: Antimetabolites
Medically reviewed by Drugs.com. Last updated on Nov 16, 2020.
- This medicine may lower the ability of the bone marrow to make blood cells that the body needs. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. If you have questions, talk with the doctor.
- This medicine may raise the risk of cancer. Do not take this medicine (cladribine tablets) if you have cancer. If you have ever had cancer, talk with your doctor.
- This medicine may cause harm to the unborn baby if you take it while pregnant. Do not take this medicine (cladribine tablets) if you are pregnant, or if you are able to get pregnant but are not using birth control.
- If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting this medicine (cladribine tablets). Talk with your doctor.
- Use birth control to prevent pregnancy during treatment and for 6 months after the last dose in your treatment cycle. If you are using birth control pills or other hormone-based birth control, use some other kind of birth control also, like a condom, during treatment and for 4 weeks after the last dose in your treatment cycle.
- If you get pregnant while taking this medicine (cladribine tablets) or within 6 months after your last dose, call your doctor right away.
- If you are a man able to father a child, do not take this medicine (cladribine tablets) if you are not using birth control. Protect your partner from pregnancy during treatment and for 6 months after the last dose of your treatment cycle.
- If you are a man and your sex partner gets pregnant while you take this medicine (cladribine tablets) or within 6 months after your last dose, call your doctor right away.
Uses of Cladribine Tablets:
- It is used to treat MS (multiple sclerosis).
What do I need to tell my doctor BEFORE I take Cladribine Tablets?
- If you have an allergy to cladribine or any other part of this medicine (cladribine tablets).
- If you are allergic to this medicine (cladribine tablets); any part of this medicine (cladribine tablets); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have any of these health problems: Kidney disease or liver disease.
- If you have any of these health problems: Hepatitis B, hepatitis C, HIV, or any other infection.
- If you have active TB (tuberculosis).
- If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with this medicine (cladribine tablets), like certain drugs that are used for hepatitis C, HIV, or infections. There are many drugs that must not be taken with this medicine (cladribine tablets).
- If you are breast-feeding. Do not breast-feed while you take this medicine (cladribine tablets) and for at least 10 days after your last dose.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (cladribine tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Cladribine Tablets?
- Tell all of your health care providers that you take this medicine (cladribine tablets). This includes your doctors, nurses, pharmacists, and dentists.
- You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- If you are not up to date with all of your vaccines, talk with your doctor. You may need to have some vaccines before treatment with this drug.
- Talk with your doctor before getting any vaccines. Use of some vaccines with this medicine (cladribine tablets) may either raise the chance of an infection or make the vaccine not work as well.
- If you have taken this medicine (cladribine tablets) and you are getting a blood transfusion, talk with your doctor.
How is this medicine (Cladribine Tablets) best taken?
Use this medicine (cladribine tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food.
- Swallow whole with a drink of water.
- Do not chew this medicine (cladribine tablets).
- If you take other drugs by mouth, take them at least 3 hours before or 3 hours after this medicine (cladribine tablets). If you are not able to do this, talk with your doctor.
- You will need to take special care when handling this medicine (cladribine tablets). Check with the doctor or pharmacist to see how to handle this medicine (cladribine tablets).
- Do not take this medicine (cladribine tablets) out of the blister pack until you are ready to take it. Take this medicine (cladribine tablets) right away after opening the blister pack. Do not store the removed drug for future use.
- Be sure your hands are dry before you touch this medicine (cladribine tablets).
- Wash your hands after use.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it on the same day you missed the dose.
- If you do not remember to take your dose until the next day, take the missed dose. Then, take your next dose the day after. Your treatment week will be 1 day longer.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
- Feeling very tired or weak.
- Shortness of breath, a big weight gain, or swelling in the arms or legs.
- A fast heartbeat.
- A heartbeat that does not feel normal.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Low mood (depression).
- A very bad brain problem called progressive multifocal leukoencephalopathy (PML) has happened with this medicine (cladribine tablets). It may cause disability or can be deadly. Tell your doctor right away if you have signs like confusion, memory problems, low mood (depression), change in the way you act, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.
What are some other side effects of Cladribine Tablets?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Cladribine Tablets?
- Store in the original container at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this medicine (cladribine tablets) is refilled. If you have any questions about this medicine (cladribine tablets), please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Frequently asked questions
- What are the new drugs used for multiple sclerosis (MS)?
- How quickly does Mavenclad work?
- Is Mavenclad a chemotherapy drug?
- Does Mavenclad cause weight gain?
- Does Mavenclad cause hair loss?
More about cladribine
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- 3 Reviews
- Drug class: antimetabolites
- Drug Information
- Cladribine injection
- Cladribine (Advanced Reading)
- Cladribine Intravenous (Advanced Reading)
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.