Ciprofloxacin extended-release tabletsPronunciation
Generic Name: ciprofloxacin (SIP-roe-FLOX-a-sin)
Brand Name: Proquin XR
Ciprofloxacin extended-release tablets are associated with an increased risk of tendon problems. These include pain, swelling, inflammation, and possible breakage of tendons. The risk of tendon problems is greater in patients who are older than 60 years old, patients who take corticosteroids (eg, prednisone), and in those who have received kidney, heart, or lung transplants. The Achilles tendon in the back of the foot/ankle is most often affected. However, problems may also occur in other tendons (eg, in the shoulder, arm, hand). Problems may occur while you take ciprofloxacin extended-release tablets or up to several months after you stop taking it.
Signs of tendon problems may include pain, soreness, redness, or swelling of a tendon or joint; bruising right after an injury in a tendon area; hearing or feeling a snap or pop in a joint or tendon area; or inability to move or bear weight on a joint or tendon area. Tell your doctor right away if you experience any of these symptoms while you take ciprofloxacin extended-release tablets or within several months after you stop taking it.
Ciprofloxacin extended-release tablets may worsen muscle weakness and breathing problems in patients with myasthenia gravis. Do not take ciprofloxacin extended-release tablets if you have a history of myasthenia gravis.
Ciprofloxacin extended-release tablets are used for:
Treating urinary tract infections caused by certain bacteria.
Ciprofloxacin extended-release tablets are a fluoroquinolone antibiotic. It works by killing sensitive bacteria.
Do NOT use ciprofloxacin extended-release tablets if:
- you are allergic to any ingredient in ciprofloxacin extended-release tablets or to any other fluoroquinolone (eg, levofloxacin)
- you have a history of myasthenia gravis
- you are taking agomelatine, lomitapide, pirfenidone, pomalidomide, or tizanidine, or you have recently received a live oral typhoid vaccine
Contact your doctor or health care provider right away if any of these apply to you.
Before using ciprofloxacin extended-release tablets:
Some medical conditions may interact with ciprofloxacin extended-release tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a stomach infection, liver problems, brain or nervous system problems, increased pressure in the brain, Alzheimer disease, brain blood vessel problems, muscle problems (eg, myasthenia gravis), or a history of seizures
- if you have a history of stroke, severe or persistent diarrhea, skin sensitivity to the sun, low blood potassium or magnesium levels, heart problems, or irregular heartbeat (eg, QT prolongation), or if you have a family member with a history of irregular heartbeat
- if you have a history of joint or tendon problems; rheumatoid arthritis; kidney problems or decreased kidney function; or a heart, kidney, or lung transplant
- if you take corticosteroids (eg, prednisone) or you participate in strenuous physical work or exercise
- if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat
Some MEDICINES MAY INTERACT with ciprofloxacin extended-release tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Antiarrhythmics (eg, amiodarone, quinidine), macrolide antibiotics (eg, clarithromycin), or methadone because the risk of serious side effects, including irregular heartbeat, may be increased
- Corticosteroids (eg, prednisone) because they may increase the risk of tendon problems
- Diuretics (eg, furosemide, hydrochlorothiazide), ketorolac, metoclopramide, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or probenecid because they may increase the risk of ciprofloxacin extended-release tablets's side effects
- Agomelatine, anticoagulants (eg, warfarin), antipsychotics (eg, clozapine, olanzapine), cyclosporine, duloxetine, lomitapide, methotrexate, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), pirfenidone, pomalidomide, ropinirole, sildenafil, sulfonylureas (eg, glyburide), theophylline, tizanidine, tricyclic antidepressants (eg, amitriptyline), or xanthines (eg, pentoxifylline) because the risk of their side effects may be increased by ciprofloxacin extended-release tablets
- Hydantoins (eg, phenytoin) or live oral typhoid vaccine because their effectiveness may be decreased by ciprofloxacin extended-release tablets
This may not be a complete list of all interactions that may occur. Ask your health care provider if ciprofloxacin extended-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use ciprofloxacin extended-release tablets:
Use ciprofloxacin extended-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Ciprofloxacin extended-release tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get ciprofloxacin extended-release tablets refilled.
- Take ciprofloxacin extended-release tablets by mouth with the evening meal, unless directed otherwise by your doctor.
- Swallow ciprofloxacin extended-release tablets whole with a full glass of water. Do not break, crush, or chew before swallowing. If you cannot swallow ciprofloxacin extended-release tablets whole, tell your doctor.
- Drinking extra fluids while you are taking ciprofloxacin extended-release tablets is recommended. Check with your doctor for instructions.
- If you also take any products containing magnesium, aluminum, calcium, iron, or zinc (eg, antacids, quinapril, vitamins/minerals); didanosine; sucralfate; or bismuth subsalicylate, do not take them within 6 hours before or 2 hours after taking ciprofloxacin extended-release tablets. Check with your doctor if you have questions.
- If you also take sevelamer, do not take it within 4 hours before or after taking ciprofloxacin extended-release tablets. Check with your doctor if you have questions.
- To clear up your infection completely, take ciprofloxacin extended-release tablets for the full course of treatment. Keep taking it even if you feel better in a few days.
- Avoid taking ciprofloxacin extended-release tablets with milk or milk products (eg, calcium-enriched juice, yogurt) by themselves. However, taking ciprofloxacin extended-release tablets as part of a full meal that contains milk or milk products is permitted.
- If you miss a dose of ciprofloxacin extended-release tablets, take it as soon as possible if you remember on the same day. If you do not remember until the next day, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses on the same day.
Ask your health care provider any questions you may have about how to use ciprofloxacin extended-release tablets.
Important safety information:
- Ciprofloxacin extended-release tablets may cause dizziness or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use ciprofloxacin extended-release tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Tell your doctor or dentist that you take ciprofloxacin extended-release tablets before you receive any medical or dental care, emergency care, or surgery.
- Be sure to use ciprofloxacin extended-release tablets for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Long-term or repeated use of ciprofloxacin extended-release tablets may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Ciprofloxacin extended-release tablets only works against bacteria; it does not treat viral infections (eg, the common cold).
- Before using ciprofloxacin extended-release tablets, tell your doctor if you take a medicine that contains caffeine or you consume large amounts of food or drink that contain caffeine (eg, coffee, tea, cocoa, cola, chocolate).
- Tell your doctor right away if you experience pain or swelling of a tendon or weakness or loss of use of a joint area. Rest the area and avoid exercise until further instruction from your doctor.
- Diabetes patients - Ciprofloxacin extended-release tablets may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Ciprofloxacin extended-release tablets may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to ciprofloxacin extended-release tablets. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
- Lab tests, including complete blood cell counts and liver and kidney function tests, may be performed while you use ciprofloxacin extended-release tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use ciprofloxacin extended-release tablets with caution in the ELDERLY; they may be more sensitive to its effects (eg, tendon problems), especially if they take corticosteroids (eg, prednisone). They may also be more sensitive to other effects (eg, irregular heartbeat).
- Ciprofloxacin extended-release tablets should be used with extreme caution in CHILDREN younger than 18 years old; they may be more sensitive to its effects, especially joint and tendon problems.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking ciprofloxacin extended-release tablets while you are pregnant. Ciprofloxacin extended-release tablets are found in breast milk. Do not breast-feed while taking ciprofloxacin extended-release tablets.
Possible side effects of ciprofloxacin extended-release tablets:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; dizziness; headache; nausea; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue); bloody or tarry stools; burning, numbness, tingling, pain, or weakness of the arms, hands, legs, or feet; change in the amount of urine produced; chest pain; fainting; fast or irregular heartbeat; fever, chills, or unusual cough; hallucinations; inability to move or bear weight on a joint or tendon area; moderate to severe sunburn; mood or mental changes (eg, new or worsening agitation, anxiety, confusion, depression, nervousness, nightmares, paranoia, restlessness, sleeplessness); muscle pain or weakness; pain, soreness, redness, swelling, weakness, or bruising of a tendon or joint area; pale stools; persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea; severe or persistent dizziness; shortness of breath or trouble breathing; stomach cramps or pain; suicidal thoughts or actions; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, unusual stomach pain, yellowing of the skin or eyes); tremors; unusual bruising or bleeding; unusual fatigue; vaginal yeast infection; vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of ciprofloxacin extended-release tablets:
Store ciprofloxacin extended-release tablets at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep ciprofloxacin extended-release tablets out of the reach of children and away from pets.
- If you have any questions about ciprofloxacin extended-release tablets, please talk with your doctor, pharmacist, or other health care provider.
- Ciprofloxacin extended-release tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take ciprofloxacin extended-release tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about ciprofloxacin extended-release tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ciprofloxacin extended-release tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using ciprofloxacin extended-release tablets.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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