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Ceftazidime and avibactam

Generic Name: ceftazidime and avibactam (sef-TAZ-i-deem & a-vi-BAK-tam)
Brand Name: Avycaz

Ceftazidime and avibactam is used for:

Treating bacterial infections.

Ceftazidime and avibactam is an antibiotic. It works by killing sensitive bacteria.

Do NOT use ceftazidime and avibactam if:

  • you are allergic to any ingredient in ceftazidime and avibactam or to another cephalosporin (eg, cephalexin)
  • you are taking probenecid

Contact your doctor or health care provider right away if any of these apply to you.

Before using ceftazidime and avibactam:

Some medical conditions may interact with ceftazidime and avibactam. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a penicillin (eg, amoxicillin) or beta-lactam antibiotic (eg, imipenem)
  • if you have kidney problems

Some MEDICINES MAY INTERACT with ceftazidime and avibactam. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Probenecid because it may increase the risk of ceftazidime and avibactam's side effects
  • Hormonal birth control (eg, birth control pills) because its effectiveness may be decreased by ceftazidime and avibactam

This may not be a complete list of all interactions that may occur. Ask your health care provider if ceftazidime and avibactam may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ceftazidime and avibactam:

Use ceftazidime and avibactam as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Ceftazidime and avibactam is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • To clear up your infection completely, use ceftazidime and avibactam for the full course of treatment. Keep using it even if you feel better in a few days.
  • If you miss a dose of ceftazidime and avibactam, call your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use ceftazidime and avibactam.

Important safety information:

  • Tell your doctor or dentist that you take ceftazidime and avibactam before you receive any medical or dental care, emergency care, or surgery.
  • Serious and sometimes deadly allergic reactions have rarely happened with medicines like this one. Discuss any questions or concerns with your doctor.
  • Ceftazidime and avibactam only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Be sure to use ceftazidime and avibactam for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of ceftazidime and avibactam may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody or watery stools occur. Do not treat diarrhea without first checking with your doctor.
  • Diabetes patients-Ceftazidime and avibactam may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using ceftazidime and avibactam. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Ceftazidime and avibactam may affect certain lab test results. Be sure your doctor and lab personnel know you are using ceftazidime and avibactam.
  • Lab tests may be performed while you use ceftazidime and avibactam. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use ceftazidime and avibactam with caution in the ELDERLY; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using this while you are pregnant. Ceftazidime and avibactam is found in breast milk. If you are or will be breast-feeding while you use ceftazidime and avibactam, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of ceftazidime and avibactam:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; dizziness; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal muscle movements; confusion; hallucinations; passing out; seizures; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of ceftazidime and avibactam:

Ceftazidime and avibactam is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.

General information:

  • If you have any questions about ceftazidime and avibactam, please talk with your doctor, pharmacist, or other health care provider.
  • Ceftazidime and avibactam is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take ceftazidime and avibactam or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about ceftazidime and avibactam. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ceftazidime and avibactam. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using ceftazidime and avibactam.

Review Date: November 3, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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