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Generic Name: lomustine (ccnu) (loe-MUS-teen)
Brand Name: Examples include CeeNU and Gleostine

CeeNU is usually taken as a single dose only once every 6 weeks. Do NOT take a dose of CeeNU more than once within a 6-week period without first talking with your doctor.

CeeNU often decreases bone marrow function and lowers the number of white blood cells and platelets in your blood. This may increase your risk for severe infection or bleeding problems, especially if you already have bone marrow suppression. The risk is greater if you take CeeNU more often than once every 6 weeks, take it in high doses, or take it for a long period of time. Tell your doctor right away if you experience symptoms such as fever, chills or persistent sore throat, unusual bruising or bleeding, or unusual tiredness or weakness.

You will need to have blood tests every week for at least 6 weeks after each single dose of CeeNU. Your doctor may change your dose of CeeNU based on these tests.

CeeNU is used for:

Treating certain types of cancer.

CeeNU is an alkylating agent used to treat cancer. It works by stopping or slowing the growth of cancer cells.

Do NOT use CeeNU if:

  • you are allergic to any ingredient in CeeNU
  • you have taken a dose of CeeNU within the past 6 weeks, unless your doctor tells you otherwise

Contact your doctor or health care provider right away if any of these apply to you.

Before using CeeNU:

Some medical conditions may interact with CeeNU. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of bone marrow, heart, lung, breathing, liver, or kidney problems
  • if you have a bacterial, fungal, or viral infection (eg, shingles, chickenpox)
  • if you are undergoing radiation therapy

Some MEDICINES MAY INTERACT with CeeNU. Tell your health care provider if you are taking any other medicines.

Ask your health care provider if CeeNU may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use CeeNU:

Use CeeNU as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • CeeNU is usually taken as a single dose only once every 6 weeks. You may receive 2 or more types or colors of capsules. Be sure you understand exactly how much of CeeNU to take and how often you should take it. Ask your doctor or pharmacist if you have any questions.
  • Take CeeNU by mouth with or without food. Taking it on an empty stomach may reduce the risk of nausea and vomiting.
  • Wear gloves when you handle CeeNU to decrease the risk of getting it on your skin or on other items. If skin contact occurs, wash the area thoroughly.
  • If you miss a dose of CeeNU, call your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use CeeNU.

Important safety information:

  • Do NOT take more than the prescribed dose or take CeeNU more often than once every 6 weeks without checking with your doctor. The risk of severe and sometimes fatal bone marrow problems may be greater if you take CeeNU in high doses or more often than once every 6 weeks.
  • Nausea, vomiting, and loss of appetite are common with CeeNU. Ask your doctor or pharmacist for ways to decrease these effects if they occur. Nausea and vomiting usually go away in less than 24 hours. Loss of appetite may last for several days.
  • CeeNU may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • CeeNU may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Talk with your doctor before you have any vaccines while you are taking CeeNU.
  • Long-term use of CeeNU may increase the risk of developing a second cancer. Discuss any questions or concerns with your doctor.
  • Severe and sometimes fatal lung problems have happened with CeeNU. Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
  • Lab tests, including liver, kidney, and lung function and complete blood cell counts, may be performed while you take CeeNU and for 6 weeks or more after you take your last dose. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Caution is advised when using CeeNU in CHILDREN; they may be more sensitive to its effects, especially certain lung problems (pulmonary fibrosis).
  • PREGNANCY and BREAST-FEEDING: CeeNU may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking CeeNU while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking CeeNU.

Possible side effects of CeeNU:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Hair loss; loss of appetite; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion or disorientation; decreased amount of urine produced; decreased coordination; fever, chills, or persistent sore throat; sluggishness; swelling of feet or lower legs; swelling or sores of the mouth or tongue; symptoms of liver problems (eg, dark urine; pale stools; right-sided stomach pain; unusual loss of appetite, nausea, or tiredness; yellowing of the skin or eyes); trouble speaking; unusual bleeding or bruising; unusual tiredness or weakness; vision changes (eg, blindness).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of CeeNU:

Store CeeNU at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Avoid temperatures higher than 104 degrees F (40 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep CeeNU out of the reach of children and away from pets.

General information:

  • If you have any questions about CeeNU, please talk with your doctor, pharmacist, or other health care provider.
  • CeeNU is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take CeeNU or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about CeeNU. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to CeeNU. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using CeeNU.

Issue Date: June 3, 2015