Generic Name: bromocriptine mesylate (BROE-moe-KRIP-teen MES-i-late)
Brand Name: Cycloset
Bromocriptine mesylate is used for:
Treating type 2 diabetes mellitus. It is used along with diet and exercise. It may also be used for other conditions as determined by your doctor.
Bromocriptine mesylate is a dopamine receptor agonist. Exactly how bromocriptine mesylate works to lower blood sugar is unknown.
Do NOT use bromocriptine mesylate if:
- you are allergic to any ingredient in bromocriptine mesylate or to ergot alkaloids
- you are breast-feeding
- you have fainting (syncopal) migraine headaches
- you are taking an antipsychotic (eg, clozapine, olanzapine, ziprasidone, haloperidol), efavirenz, an ergot alkaloid (eg, ergotamine), metoclopramide, a phenothizine (eg, chlorpromazine), a serotonin 5-HT1 receptor agonist (eg, sumatriptan), or a thioxanthene (eg, thiothixene)
Contact your doctor or health care provider right away if any of these apply to you.
Before using bromocriptine mesylate:
Some medical conditions may interact with bromocriptine mesylate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of low blood pressure, type 1 diabetes, high blood ketone or acid levels (eg, diabetic ketoacidosis), or kidney or liver problems
- if you have a history of mental illness (eg, psychotic disorder), migraine headaches, or if you have ever fainted
Some MEDICINES MAY INTERACT with bromocriptine mesylate. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Serotonin 5-HT1 receptor agonists (eg, sumatriptan) or sympathomimetics (eg, albuterol, pseudoephedrine) because high blood pressure or fast heartbeat may occur
- Azole antifungals (eg, ketoconazole), efavirenz, ergot alkaloids (eg, ergotamine), HIV protease inhibitors (eg, ritonavir), macrolides (eg, erythromycin), medicine for high blood pressure, or telithromycin because they may increase the risk of bromocriptine mesylate's side effects
- Antipsychotics (eg, clozapine, olanzapine, ziprasidone , haloperidol), metoclopramide, phenothiazines (eg, chlorpromazine), or thioxanthenes (eg, thiothixene) because they may decrease bromocriptine mesylate's effectiveness
- Chloramphenicol, probenecid, salicylates (eg, aspirin), or sulfonamides (eg, glipizide) because the risk of their side effects may be increased by bromocriptine mesylate
This may not be a complete list of all interactions that may occur. Ask your health care provider if bromocriptine mesylate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use bromocriptine mesylate:
Use bromocriptine mesylate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with bromocriptine mesylate. Talk to your pharmacist if you have questions about this information.
- Take bromocriptine mesylate by mouth with food within 2 hours after waking in the morning.
- Take bromocriptine mesylate on a regular schedule to get the most benefit from it.
- Bromocriptine mesylate works best if it is taken at the same time each day.
- If you miss your morning dose of bromocriptine mesylate, wait until the next morning to take it. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use bromocriptine mesylate.
Important safety information:
- Bromocriptine mesylate may cause drowsiness, dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use bromocriptine mesylate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Bromocriptine mesylate may cause dizziness, lightheadedness, or fainting. This may be more likely to occur when you first start bromocriptine mesylate or if your dose increases; however, it may occur at any time while you are taking bromocriptine mesylate. Alcohol, hot weather, exercise, and fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of these effects.
- Do NOT take more than the recommended dose, take bromocriptine mesylate more often than prescribed, or suddenly stop taking bromocriptine mesylate without first checking with your doctor.
- Follow the diet and exercise program given to you by your health care provider.
- Tell your doctor or dentist that you take bromocriptine mesylate before you receive any medical or dental care, emergency care, or surgery.
- Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take bromocriptine mesylate exactly as prescribed, tell your doctor.
- Bromocriptine mesylate may cause low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or increase hunger. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
- Fever, infection, injury, or surgery may increase your risk for high or low blood sugar levels. If any of these occur, check your blood sugar closely and tell your doctor right away.
- Lab tests, including blood sugar levels, hemoglobin A1c, and blood pressure, may be performed to monitor your progress. Be sure to keep all doctor and lab appointments.
- Use bromocriptine mesylate with caution in the ELDERLY; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in the elderly.
- Bromocriptine mesylate should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking bromocriptine mesylate while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking bromocriptine mesylate.
Possible side effects of bromocriptine mesylate:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; diarrhea; dizziness; drowsiness; fatigue; headache; indigestion; lightheadedness; loss of appetite; nausea; stuffy or runny nose; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; mental or mood changes (eg, depression); one-sided weakness; severe or persistent dizziness or drowsiness; severe or persistent headache; shortness of breath; slurred speech or trouble speaking; stomach pain; sudden confusion; sudden loss of coordination; symptoms of low blood sugar (eg, fast heartbeat, increased hunger, chills, tremor, unusual sweating, unusual weakness); vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; delusions; general feeling of discomfort; hallucinations; increased sweating; pale skin; repetitive yawning; severe dizziness; sluggishness; tiredness; vomiting.Proper storage of bromocriptine mesylate:
Store bromocriptine mesylate at or below 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep bromocriptine mesylate out of the reach of children and away from pets.
- If you have any questions about bromocriptine mesylate, please talk with your doctor, pharmacist, or other health care provider.
- Bromocriptine mesylate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take bromocriptine mesylate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about bromocriptine mesylate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to bromocriptine mesylate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using bromocriptine mesylate.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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- Drug class: dopaminergic antiparkinsonism agents