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Generic Name: ibandronate (EYE-ban-DROE-nate)
Brand Name: Boniva

Boniva is used for:

Preventing and treating osteoporosis (weak bones) in women who are past menopause. It may also be used for other conditions as determined by your doctor.

Boniva is a bisphosphonate. It works by slowing bone loss and allowing new bone to be formed.

Do NOT use Boniva if:

  • you are allergic to any ingredient in Boniva
  • you have certain esophagus problems (eg, narrowing, blockage)
  • you have severe kidney problems or low levels of calcium in your blood
  • you cannot stand or sit upright for at least 60 minutes

Contact your doctor or health care provider right away if any of these apply to you.

Before using Boniva:

Some medical conditions may interact with Boniva. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of stomach or bowel problems (eg, inflammation, ulcer), esophagus problems (eg, narrowing, blockage, heartburn, reflux disease, severe irritation), or kidney problems, or if you have difficult or painful swallowing
  • if you have low blood vitamin D levels, cancer, anemia, asthma, blood clotting problems, an infection, calcium metabolism problems, or nutrient absorption problems (eg, malabsorption syndrome), or you are unable to take calcium or vitamin D supplements
  • if you have poor dental hygiene or other dental problems, or if you will be having a dental procedure (eg, tooth extraction)
  • if you smoke or drink alcohol
  • if you have had or will be having chemotherapy or radiation treatment
  • if you have a mental disorder or other condition that may decrease your ability to follow the dosing instructions for Boniva
  • if you are taking any medicines that can cause jaw bone problems. There are many medicines that can do this. Ask your doctor or pharmacist if you are not sure

Some MEDICINES MAY INTERACT with Boniva. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of stomach irritation, including ulcers, may be increased
  • Corticosteroids (eg, prednisone) or angiogenesis inhibitors (eg, bevacizumab) because the risk of jawbone problems may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Boniva may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Boniva:

Use Boniva as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Boniva comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Boniva refilled.
  • Take Boniva by mouth on an empty stomach at least 1 hour before eating. Boniva is only effective when taken on an empty stomach.
  • Take Boniva with 6 to 8 ounces (180 to 240 mL) of plain water (not mineral water) first thing in the morning at least 60 minutes before you take any other medicines or drink anything other than plain water.
  • Swallow Boniva whole. Do not break, crush, chew, or suck on the tablet before swallowing.
  • Do NOT lie down for 60 minutes after taking Boniva.
  • Calcium or iron supplements, vitamins, or antacids containing calcium, magnesium, or aluminum may interfere with the absorption of Boniva. Take these products and any other medicines at least 1 hour after taking Boniva.
  • If you miss a dose of Boniva and your next scheduled dose is more than 7 days away, take 1 dose in the morning on the day after you remember and then return to your original schedule. Do not take 2 doses within the same week. If your next scheduled dose is 1 to 7 days away, skip the missed dose and go back to your regular dosing schedule. If you miss a dose of Boniva and you are unsure of what to do, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Boniva.

Important safety information:

  • Tell your doctor or dentist that you take Boniva before you receive any medical or dental care, emergency care, or surgery.
  • Boniva may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Boniva with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Boniva can cause pain or trouble swallowing, heartburn, or, rarely, ulcers in your stomach or esophagus. Taking Boniva with plenty of water and not lying down for at least 1 hour afterward will help to reduce your risk of these problems. Discuss the benefits and risks of Boniva with your doctor.
  • Follow the diet and exercise program given to you by your health care provider. Talk to your doctor about whether you should take a calcium and vitamin D supplement while you take Boniva.
  • Talk to your doctor about the use of weight-bearing exercises to help prevent weak bones.
  • Certain fractures of the thigh bone (femur) have been reported in patients using bisphosphonates. It is unknown if bisphosphonates contributed to the fractures. Contact your doctor right away if you experience hip, thigh, or groin pain. Discuss any questions or concerns with your doctor.
  • Boniva may cause jawbone problems in some patients. Your risk may be greater the longer you take Boniva or if you have cancer, poor dental hygiene, or certain other conditions (eg, anemia, blood clotting problems, infection, dental problems). Your risk may also be greater if you have certain dental procedures or you are using certain medicines or therapies (eg, chemotherapy, corticosteroids, radiation). Talk to your doctor about having a dental exam before starting Boniva. Ask your doctor any questions you may have about dental treatment while you take Boniva.
  • Proper dental care is important while you are taking Boniva. Brush and floss your teeth and visit the dentist regularly.
  • Certain dental procedures should be avoided if possible while you are using Boniva. Tell your doctor or dentist that you take Boniva before you receive any medical or dental care, emergency care, or surgery.
  • Worsening of asthma has been reported in patients taking medicines like this one. Discuss any questions or concerns with your doctor.
  • Boniva may interfere with certain lab or diagnostic tests that use a bone-imaging agent. Be sure your doctor and lab personnel know that you are taking Boniva.
  • Lab tests, including bone thickness or density and blood calcium levels, may be performed while you use Boniva. These tests may be used to monitor your condition or check for side effects. Your doctor may also want to evaluate you periodically while you take Boniva to assess the need to continue its treatment. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Boniva while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you take Boniva, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Boniva:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; mild arm, back, leg, muscle, or joint pain; mild flu-like symptoms; stomach pain or upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; fainting; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); bloody or black, tarry stools; chest pain; coughing up blood; eye pain; mouth sores; new, worsening, or persistent heartburn; painful or difficult swallowing; painful or difficult urination; severe bone, joint, or muscle pain (especially in the hip, groin, or thigh); severe or persistent dizziness or headache; severe or persistent stomach pain; swelling or pain in your jaw; symptoms of low blood calcium (eg, spasms, twitches, or cramps in your muscles; numbness or tingling in your fingers, toes, or around your mouth); vision changes; vomiting blood or a substance that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Do not lie down. Do not try to vomit.

Proper storage of Boniva:

Store Boniva at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Boniva out of the reach of children and away from pets.

General information:

  • If you have any questions about Boniva, please talk with your doctor, pharmacist, or other health care provider.
  • Boniva is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Boniva or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Boniva. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Boniva. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Boniva.

Review Date: November 3, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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