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Benzoyl peroxide/ urea cream

Generic Name: benzoyl peroxide/urea (BEN-zoe-ill per-OX-ide/yoo-REE-ah)
Brand Name: ZoDerm

Benzoyl peroxide/ urea cream is used for:

Treating acne.

Benzoyl peroxide/urea cream is a keratolytic agent with antibacterial actions. The effectiveness of benzoyl peroxide appears to be due to its antibacterial, peeling (keratolytic), and drying actions.

Do NOT use benzoyl peroxide/ urea cream if:

  • you are allergic to any ingredient in benzoyl peroxide/urea cream

Contact your doctor or health care provider right away if any of these apply to you.

Before using benzoyl peroxide/ urea cream:

Some medical conditions may interact with benzoyl peroxide/urea cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with benzoyl peroxide/urea cream. Because little, if any, of benzoyl peroxide/urea cream is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if benzoyl peroxide/urea cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use benzoyl peroxide/ urea cream:

Use benzoyl peroxide/urea cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • To use the gel - Wash and completely dry the affected area. Gently rub the medicine in until it is evenly distributed.
  • Wash your hands immediately after using benzoyl peroxide/urea cream.
  • Contact your doctor if the affected area becomes too dry or if excessive irritation develops. You may need to use less medicine or apply the medicine less often.
  • Several weeks may pass before you see improvement in your acne. Continue to use benzoyl peroxide/urea cream for the full time recommended by your doctor. If your acne does not improve or if it gets worse, check with your doctor.
  • If you miss a dose of benzoyl peroxide/urea cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use benzoyl peroxide/urea cream.

Important safety information:

  • Certain acne products that contain benzoyl peroxide or salicylic acid can rarely cause serious and sometimes life-threatening allergic reactions or severe irritation. Before first use, you may need to follow certain steps to make sure you do not have an allergic reaction. Use benzoyl peroxide/urea cream as you were told by your doctor or read the package label. Discuss any questions or concerns with your doctor.
  • Use on the skin only. Avoid getting benzoyl peroxide/urea cream in your eyes, on the inside of your nose or mouth, on highly inflamed or damaged skin, or on your lips. If you get benzoyl peroxide/urea cream in your eyes, immediately wash them out with cool tap water.
  • Avoid applying benzoyl peroxide/urea cream to raw or irritated skin, including sunburns, or to open wounds.
  • Several weeks may pass before you see improvement in your acne. Continue to use benzoyl peroxide/urea cream for the full time recommended by your doctor. If your acne does not improve or if it gets worse, check with your doctor.
  • Talk with your doctor before you use any other medicines, special cleansers, aftershave, or cosmetics on your skin without checking with your doctor.
  • Benzoyl peroxide/urea cream may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to benzoyl peroxide/urea cream. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Benzoyl peroxide/urea cream may cause bleaching. Avoid contact with hair, fabrics, or carpeting.
  • Benzoyl peroxide/urea cream should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using benzoyl peroxide/urea cream while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use benzoyl peroxide/urea cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of benzoyl peroxide/ urea cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dryness; feeling of warmth; irritation; itching; peeling; redness; stinging; swelling of the skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; dizziness; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); excessive burning, itching, redness, or tenderness of your skin; extreme dryness; swelling.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include excessive scaling; flushing; redness; swelling.

Proper storage of benzoyl peroxide/urea cream:

Store at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container, away from fire, flame, heat, and light. Do not store in the bathroom. Keep benzoyl peroxide/urea cream out of the reach of children and away from pets.

General information:

  • If you have any questions about benzoyl peroxide/urea cream, please talk with your doctor, pharmacist, or other health care provider.
  • Benzoyl peroxide/urea cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take benzoyl peroxide/urea cream or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about benzoyl peroxide/urea cream. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to benzoyl peroxide/urea cream. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using benzoyl peroxide/urea cream.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.