Generic Name: rasagiline (ra-SA-ji-leen)
Brand Name: Azilect
Azilect is used for:
Treating Parkinson disease. It may also be used for other conditions as determined by your doctor.
Azilect is a monoamine oxidase inhibitor (MAOI). Exactly how it works is not known. It may help to increase a substance in the brain that affects motor function.
Do NOT use Azilect if:
- you are allergic to any ingredient in Azilect
- you have moderate to severe liver problems
- you are taking fluoxetine or have taken it within the past 5 weeks
- you are taking selegiline or another MAOI (eg, phenelzine) or if you have taken any of these medicines within the past 14 days
- you are taking cyclobenzaprine, dextromethorphan, meperidine, methadone, propoxyphene, a selective serotonin reuptake inhibitor (SSRI) (eg, paroxetine), a serotonin-norepinephrine reuptake inhibitor (SNRI) (eg, venlafaxine, duloxetine), St. John's wort, a tetracyclic antidepressant (eg, mirtazapine), tramadol, trazodone, a tricyclic antidepressant (eg, amitriptyline), or vilazodone
Contact your doctor or health care provider right away if any of these apply to you.
Before using Azilect:
Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of skin cancer or uncontrolled muscle movements (eg, twitching of the face and tongue and involuntary movements of the arms and legs)
- if you have a history of liver problems, kidney problems, sleep problems, or high or low blood pressure
- if you have certain adrenal gland problems (pheochromocytoma) or a history of mental or mood problems
Some MEDICINES MAY INTERACT with Azilect. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Cyclobenzaprine, dextromethorphan, other MAOIs (eg, phenelzine, selegiline), meperidine, methadone, propoxyphene, SNRIs (eg, venlafaxine, duloxetine), SSRIs (eg, fluoxetine, paroxetine), St. John's wort, sympathomimetics (eg, amphetamines, pseudoephedrine, phenylephrine, ephedrine), tetracyclic antidepressants (eg, mirtazapine), tramadol, trazodone, or tricyclic antidepressants (eg, amitriptyline), or vilazodone because serious effects, including severe high blood pressure or a condition called serotonin syndrome may occur
- Levodopa because the risk of uncontrolled muscle movements, hallucinations, or light-headedness when you sit up or stand may be increased
- Ciprofloxacin because it may increase the risk of Azilect's side effects
- Metoclopramide or certain medicines for mood problems because they may decrease Azilect's effectiveness
Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Azilect:
Use Azilect as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Azilect by mouth with or without food.
- Do not suddenly stop taking Azilect without checking with your doctor. You may experience side effects such as fever or confusion.
- If you miss a dose of Azilect, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Azilect.
Important safety information:
- Azilect may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Azilect with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Check with your doctor before you drink alcohol while you are taking Azilect.
- Azilect may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Some patients who take Azilect have reported suddenly falling asleep while performing daily activities (eg, driving, eating, talking). Some patients did not experience drowsiness and felt that they were alert immediately before suddenly falling asleep. Some of these events have been reported as late as 1 year after Azilect was started. Use caution when driving, operating machinery, or performing other activities that could be dangerous. Inform your doctor if you experience unusual drowsiness or sleepiness while using Azilect.
- Eating certain foods that contain very high amounts of tyramine (eg, aged cheeses) while you take Azilect may cause severe high blood pressure. Other foods that contain tyramine (eg, red wines, beer, certain meats and sausages, liver, sour cream, soy sauce, raisins, bananas, avocados) are NOT likely to cause such a reaction with recommended doses of Azilect. However, seek medical attention at once if symptoms of severe high blood pressure occur. These may include severe headache, fast or irregular heartbeat, sore or stiff neck, nausea, vomiting, sweating, enlarged pupils, or sensitivity to light.
- Do NOT take more than the recommended dose of Azilect without checking with your doctor. Taking more than the recommended dose may increase your risk of high blood pressure. Discuss any questions with your doctor.
- Tell your doctor or dentist that you take Azilect before you receive any medical or dental care, emergency care, or surgery.
- Some people have experienced new, unusual, or increased urges (eg, gambling, sexual urges) while using Azilect. Tell your doctor right away if you notice such effects.
- If your doctor tells you to stop taking Azilect, you will need to wait at least 14 days before beginning to take certain other medicines (eg, medicines for depression, anxiety, pain, cough, congestion, weight loss, Parkinson disease; muscle relaxants). Ask your doctor if you are unsure when you should start to take your new medicines after you have stopped taking Azilect.
- Serotonin syndrome is a possibly fatal syndrome that can be caused if Azilect is taken with certain other medicines (eg, other MAOIs, medicines for depression). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
- Azilect may cause high blood pressure. Have your blood pressure checked while taking Azilect. Discuss any questions or concerns with your doctor.
- Patients with Parkinson disease may have an increased risk of developing a certain type of skin cancer (melanoma). It is not known if Azilect also increases the risk of melanoma. You may need to have skin exams while you are using Azilect. Discuss any questions or concerns with your doctor.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Azilect while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you take Azilect, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Azilect:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; diarrhea; dizziness; drowsiness; dry mouth; flu-like symptoms; headache; joint pain; loss of appetite, mild stomach pain; nausea; stomach upset; stuffy nose; vomiting; weight loss.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; blood in the urine; blurred vision or other vision changes; burning, numbness, or tingling; changes in sexual ability or desire; chest pain; confusion; decreased coordination; enlarged pupils; eye pain or inflammation; fainting; fast or irregular heartbeat; fever; hallucinations; inability to sit still; mental, mood, or behavior changes (eg, agitation, depression, paranoia); one-sided weakness; seizures; sensitivity to light; severe or persistent headache, dizziness, or light-headedness; severe or persistent nausea, vomiting, stomach pain, or diarrhea; shortness of breath; skin changes; sore or stiff neck; speech problems; stiff muscles; swelling of the hands, ankles, or feet; tremor; trouble thinking or walking; unusual sweating.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Azilect:
Store Azilect at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Azilect out of the reach of children and away from pets.
- If you have any questions about Azilect, please talk with your doctor, pharmacist, or other health care provider.
- Azilect is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Azilect or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Azilect. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Azilect. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Azilect.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Azilect (rasagiline)
- Side Effects
- During Pregnancy
- Dosage Information
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- Drug Interactions
- Support Group
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