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Antithrombin (recombinant)

Generic Name: antithrombin (recombinant) (AN-tee-THROM-bin)
Brand Name: ATryn

Antithrombin (recombinant) is used for:

Preventing perioperative and peripartum thromboembolic events in hereditary antithrombin deficient patients.

Antithrombin (recombinant) is a recombinant antithrombin. It works by regulating the clotting and inflammatory processes that lead to the formation of blood clots.

Do NOT use antithrombin (recombinant) if:

  • you are allergic to any ingredient in antithrombin (recombinant), or to goat or goat milk proteins

Contact your doctor or health care provider right away if any of these apply to you.

Before using antithrombin (recombinant):

Some medical conditions may interact with antithrombin (recombinant). Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances

Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, heparin) because the risk of bleeding may be increased by antithrombin (recombinant)

This may not be a complete list of all interactions that may occur. Ask your health care provider if antithrombin (recombinant) may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use antithrombin (recombinant):

Use antithrombin (recombinant) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with antithrombin (recombinant). Talk to your pharmacist if you have questions about this information.
  • Antithrombin (recombinant) is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using antithrombin (recombinant) at home, a health care provider will teach you how to use it. Be sure you understand how to use antithrombin (recombinant). Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not shake antithrombin (recombinant).
  • Do not use antithrombin (recombinant) if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of antithrombin (recombinant), contact your doctor right away.

Ask your health care provider any questions you may have about how to use antithrombin (recombinant).

Important safety information:

  • Antithrombin (recombinant) may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Lab tests, including aPTT and anti-factor Xa activity, may be performed while you use antithrombin (recombinant). These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use antithrombin (recombinant) with caution in the ELDERLY; they may be more sensitive to its effects.
  • Antithrombin (recombinant) should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Antithrombin (recombinant) has not been shown to cause harm to the fetus if you take it while you are pregnant. If you become pregnant, contact your doctor. Your dose may need to be changed. Antithrombin (recombinant) is found in breast milk. If you are or will be breast-feeding while you use antithrombin (recombinant), check with your doctor. Discuss any possible risks to your baby.

Possible side effects of antithrombin (recombinant):

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild bleeding, redness, swelling, or itching at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; chest pain; dizziness; fainting; fatigue; unusual bruising or bleeding; weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of antithrombin (recombinant):

Store antithrombin (recombinant) in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Do not use medicine after the expiration date printed on the package. Discard unused portions. Keep antithrombin (recombinant) out of the reach of children and away from pets.

General information:

  • If you have any questions about antithrombin (recombinant), please talk with your doctor, pharmacist, or other health care provider.
  • Antithrombin (recombinant) is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take antithrombin (recombinant) or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about antithrombin (recombinant). It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to antithrombin (recombinant). This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using antithrombin (recombinant).

Review Date: November 3, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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