Amitriptyline and Chlordiazepoxide
Generic Name: Amitriptyline and Chlordiazepoxide (a mee TRIP ti leen & klor dye az e POKS ide)
Medically reviewed on Nov 7, 2018
- Drugs like this one have raised the chance of suicidal thoughts or actions in children and young adults. The risk may be greater in people who have had these thoughts or actions in the past. All people who take amitriptyline and chlordiazepoxide need to be watched closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
- This medicine is not approved for use in children. Talk with the doctor.
- This medicine is a benzodiazepine. The use of a benzodiazepine drug along with opioid drugs has led to very bad side effects. Side effects that have happened include slowed or trouble breathing and death. Opioid drugs include drugs like codeine, oxycodone, and morphine. Opioid drugs are used to treat pain and some are used to treat cough. Talk with the doctor.
- If you are taking amitriptyline and chlordiazepoxide with an opioid drug, get medical help right away if you feel very sleepy or dizzy; if you have slow, shallow, or trouble breathing; or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
Uses of Amitriptyline and Chlordiazepoxide:
- It is used to treat low mood (depression).
- It is used to treat anxiety.
What do I need to tell my doctor BEFORE I take Amitriptyline and Chlordiazepoxide?
- If you have an allergy to amitriptyline, chlordiazepoxide, or any other part of amitriptyline and chlordiazepoxide.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have had a recent heart attack.
- If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking amitriptyline and chlordiazepoxide within 14 days of those drugs can cause very bad high blood pressure.
- If you are taking any of these drugs: Linezolid or methylene blue.
- If you are breast-feeding. Do not breast-feed while you take amitriptyline and chlordiazepoxide.
This is not a list of all drugs or health problems that interact with amitriptyline and chlordiazepoxide.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take amitriptyline and chlordiazepoxide with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Amitriptyline and Chlordiazepoxide?
- Tell all of your health care providers that you take amitriptyline and chlordiazepoxide. This includes your doctors, nurses, pharmacists, and dentists. This medicine may need to be stopped before certain types of surgery as your doctor has told you. If amitriptyline and chlordiazepoxide is stopped, your doctor will tell you when to start taking amitriptyline and chlordiazepoxide again after your surgery or procedure.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how amitriptyline and chlordiazepoxide affects you.
- This medicine may be habit-forming with long-term use.
- Do not stop taking amitriptyline and chlordiazepoxide all of a sudden without calling your doctor. You may have a greater risk of signs of withdrawal. If you need to stop amitriptyline and chlordiazepoxide, you will want to slowly stop it as ordered by your doctor.
- Have your blood work checked if you are on amitriptyline and chlordiazepoxide for a long time. Talk with your doctor.
- Avoid drinking alcohol while taking amitriptyline and chlordiazepoxide.
- Talk with your doctor before you use other drugs and natural products that slow your actions.
- This medicine may make you sunburn more easily. Use care if you will be in the sun. Tell your doctor if you sunburn easily while taking this drug.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
- Tell your doctor if you have signs of high or low blood sugar like breath that smells like fruit, dizziness, fast breathing, fast heartbeat, feeling confused, feeling sleepy, feeling weak, flushing, headache, more thirsty or hungry, passing urine more often, shaking, or sweating.
- If you are 65 or older, use amitriptyline and chlordiazepoxide with care. You could have more side effects.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant, especially in the first trimester.
- If you are pregnant or you get pregnant while taking amitriptyline and chlordiazepoxide, call your doctor right away.
How is this medicine (Amitriptyline and Chlordiazepoxide) best taken?
Use amitriptyline and chlordiazepoxide as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- To gain the most benefit, do not miss doses.
- Keep taking amitriptyline and chlordiazepoxide as you have been told by your doctor or other health care provider, even if you feel well.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of high or low blood pressure like very bad headache or dizziness, passing out, change in eyesight.
- Hallucinations (seeing or hearing things that are not there).
- Chest pain or pressure or a fast heartbeat.
- A heartbeat that does not feel normal.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Not able to focus.
- Change in sex interest.
- A burning, numbness, or tingling feeling that is not normal.
- Feeling confused.
- Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
- Very bad belly pain.
- Very hard stools (constipation).
- Trouble passing urine.
- Swelling of the testicles.
- Enlarged breasts.
- Nipple discharge.
- Yellow skin or eyes.
- Some people may have a higher chance of eye problems with amitriptyline and chlordiazepoxide. Your doctor may want you to have an eye exam to see if you have a higher chance of these eye problems. Call your doctor right away if you have eye pain, change in eyesight, or swelling or redness in or around the eye.
- Low blood cell counts have happened with amitriptyline and chlordiazepoxide. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. Call your doctor right away if you have signs of infection like fever, chills, or sore throat; any unexplained bruising or bleeding; or if you feel very tired or weak.
What are some other side effects of Amitriptyline and Chlordiazepoxide?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling sleepy.
- Dry mouth.
- Hard stools (constipation).
- Not hungry.
- Feeling tired or weak.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Amitriptyline and Chlordiazepoxide?
- Store at room temperature.
- Protect from light.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time amitriptyline and chlordiazepoxide is refilled. If you have any questions about amitriptyline and chlordiazepoxide, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about amitriptyline/chlordiazepoxide
- Amitriptyline/chlordiazepoxide Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 7 Reviews
- Drug class: psychotherapeutic combinations
- FDA Alerts (1)