Amikacin (Systemic)

Generic name: Amikacin (systemic) [ am-i-KAY-sin ]
Drug class: Aminoglycosides

Medically reviewed by Drugs.com. Last updated on Oct 18, 2023.

Warning

This medicine may cause kidney, nerve, and hearing problems (like long-lasting hearing loss), even at normal doses. The risk may be higher if you already have kidney or hearing problems, you take higher doses, or you use amikacin (systemic) for a long time. The risk may be higher in older people, infants, or with dehydration. Hearing loss can happen even after amikacin (systemic) is stopped. If you already have kidney problems or hearing problems, tell your doctor. You may need to have hearing and kidney tests.
Do not use amikacin (systemic) if you are taking or have recently taken any drugs that can cause nerve, kidney, or hearing problems. This may be drugs like amphotericin B, bacitracin, cephaloridine, cisplatin, colistin, cyclosporine, ethacrynic acid, furosemide, paromomycin, polymyxin B, vancomycin, viomycin, or other drugs like this one. There are many other drugs that can do this. Ask your doctor or pharmacist if you are not sure.
Severe muscle problems and severe breathing problems have happened. The risk is higher if you are getting certain drugs used to put you to sleep or to relax your muscles. The risk is also higher if you are getting a certain type of blood transfusion. If you have questions, talk with your doctor.

Uses of Amikacin:

It is used to treat bacterial infections.

What do I need to tell my doctor BEFORE I take Amikacin?

If you have an allergy to amikacin or any other part of amikacin (systemic).
If you are allergic to amikacin (systemic); any part of amikacin (systemic); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
If you are breast-feeding or plan to breast-feed.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take amikacin (systemic) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Amikacin?

Tell all of your health care providers that you take amikacin (systemic). This includes your doctors, nurses, pharmacists, and dentists.
If you are allergic to sulfites, talk with your doctor. Some products have sulfites.
Have blood work checked as you have been told by the doctor. Talk with the doctor.
Do not use longer than you have been told. A second infection may happen.
If you are 65 or older, use amikacin (systemic) with care. You could have more side effects.
Use with care in newborns. Talk with the doctor.
This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking amikacin (systemic), call your doctor right away.

How is this medicine (Amikacin) best taken?

Use amikacin (systemic) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

It is given as a shot into a muscle or as an infusion into a vein over a period of time.
Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

What do I do if I miss a dose?

Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
Change in balance.
Ringing in the ears, hearing loss, or any other changes in hearing.
Muscle weakness.
A burning, numbness, or tingling feeling that is not normal.
Twitching.
Seizures.
Trouble breathing, slow breathing, or shallow breathing.
Diarrhea is common with antibiotics. Rarely, a severe form called C diff–associated diarrhea (CDAD) may happen. Sometimes, this has led to a deadly bowel problem (colitis). CDAD may happen during or a few months after taking antibiotics. Call your doctor right away if you have stomach pain, cramps, or very loose, watery, or bloody stools. Check with your doctor before treating diarrhea.

What are some other side effects of Amikacin?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

Diarrhea.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Amikacin?

If you need to store amikacin (systemic) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

If your symptoms or health problems do not get better or if they become worse, call your doctor.
Do not share your drugs with others and do not take anyone else's drugs.
Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about amikacin (systemic), please talk with your doctor, nurse, pharmacist, or other health care provider.
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.