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Alglucosidase Alfa

Generic name: Alglucosidase Alfa (al gloo KOSE i dase AL fa)
Brand name: Lumizyme
Drug class: Lysosomal enzymes

Medically reviewed by Last updated on Nov 30, 2020.


  • Very bad and sometimes life-threatening allergic reactions have happened with alglucosidase alfa. These reactions have happened during infusion and up to 3 hours after it is done.
  • During or after the infusion, tell your doctor if you have back pain; bluish skin or nails; an abnormal burning, numbness, or tingling feeling; chest pain; cough; dizziness or passing out; fast or trouble breathing; fast, slow, or abnormal heartbeat; feeling hot or cold; feeling agitated, nervous, or restless; fever or chills; flushing; headache; hives; itching; pale skin; rash; seizures; shakiness; sweating more than normal; swelling; tightness in the chest or throat; twitching; upset stomach or throwing up; or wheezing.
  • Tell your doctor if you have any heart or lung problems. If you have a reaction to alglucosidase alfa, your heart or lung problem may get worse. Talk with your doctor.

Uses of Alglucosidase Alfa:

  • It is used to treat Pompe disease.

What do I need to tell my doctor BEFORE I take Alglucosidase Alfa?

  • If you have an allergy to alglucosidase alfa or any other part of alglucosidase alfa.
  • If you are allergic to alglucosidase alfa; any part of alglucosidase alfa; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take alglucosidase alfa with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Alglucosidase Alfa?

  • Tell all of your health care providers that you take alglucosidase alfa. This includes your doctors, nurses, pharmacists, and dentists.
  • If you will be getting anesthesia, talk with your doctor. The chance of a heartbeat that is not normal and sudden death caused by heart problems may be raised in some people.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Have your urine checked as you have been told by your doctor.
  • Very bad reactions like kidney problems and skin reactions have happened after treatment with alglucosidase alfa. These reactions have happened several weeks to 3 years after treatment started. Talk with the doctor.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is this medicine (Alglucosidase Alfa) best taken?

Use alglucosidase alfa as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Any skin change.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.
  • Muscle pain.
  • Feeling very tired or weak.

What are some other side effects of Alglucosidase Alfa?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Alglucosidase Alfa?

  • If you need to store alglucosidase alfa at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about alglucosidase alfa, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.