Generic Name: alendronate (a-LEN-droe-nate)
Brand Name: Fosamax
Alendronate solution is used for:
Treating and preventing osteoporosis in certain patients. It may also be used for other conditions as determined by your doctor.
Alendronate solution is a bisphosphonate. It works by slowing bone loss.
Do NOT use alendronate solution if:
- you are allergic to any ingredient in alendronate solution
- you have certain esophagus problems (eg, narrowing, blockage)
- you are unable to stand or sit upright for at least 30 minutes
- you have low blood calcium levels or severe kidney problems
- you are at risk of aspiration (inhaling foreign matter into the airway or lungs)
Contact your doctor or health care provider right away if any of these apply to you.
Before using alendronate solution:
Some medical conditions may interact with alendronate solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of stomach or bowel problems (eg, inflammation, ulcer), esophagus problems (eg, heartburn, reflux disease, severe irritation), or kidney problems, or if you have difficult or painful swallowing
- if you are bedridden or have a history of aspiration
- if you have low blood vitamin D levels, cancer, anemia, asthma, blood clotting problems, an infection, calcium metabolism problems, or nutrient absorption problems (eg, malabsorption syndrome), or you are unable to take calcium or vitamin D supplements
- if you have poor dental hygiene or other dental problems, or you will be having a dental procedure (eg, tooth extraction)
- if you smoke or drink alcohol
- if you have had or will be having chemotherapy or radiation treatment
- if you have a mental disorder or other condition that may decrease your ability to follow the dosing instructions for alendronate solution
- if you are taking any medicines that can cause jaw bone problems. There are many medicines that can do this. Ask your doctor or pharmacist if you are not sure.
Some MEDICINES MAY INTERACT with alendronate solution. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of side effects, such as esophagus or stomach irritation, may be increased
- Corticosteroids (eg, prednisone) or angiogenesis inhibitors (eg, bevacizumab) because the risk of jawbone problems may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if alendronate solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use alendronate solution:
Use alendronate solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Alendronate solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get alendronate solution refilled.
- Be sure you understand how much of alendronate solution to take for your dose.
- Take alendronate solution by mouth on an empty stomach in the morning at least 30 minutes before your first food, drink, or other medicine of the day. Do NOT take alendronate solution at bedtime or before you get out of bed in the morning.
- Drink at least 2 oz (1/4 cup) of plain water after you take alendronate solution. Do not take alendronate solution with mineral water, coffee, tea, or juice. Do not lie down for 30 minutes after taking alendronate solution and until you eat your first food of the day.
- Alendronate solution is usually taken 1 time each week. Be sure you understand how to take alendronate solution. Contact your doctor or pharmacist if you have any questions.
- Continue to take alendronate solution even if you feel well. Do not miss any doses.
- If you miss a dose of alendronate solution, do not take it later in the day. Take it the morning after you remember, and then go back to your regular dosing schedule. Do not take 2 doses within the same day.
Ask your health care provider any questions you may have about how to use alendronate solution.
Important safety information:
- Tell your doctor or dentist that you take alendronate solution before you receive any medical or dental care, emergency care, or surgery.
- Alendronate solution may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use alendronate solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Talk with your doctor before you drink alcohol, smoke, or use other tobacco products while taking alendronate solution.
- Follow the diet and exercise program given to you by your health care provider. Talk to your doctor about whether you should take a calcium and vitamin D supplement while you use alendronate solution.
- Talk to your doctor about the use of weight-bearing exercises to help prevent weak bones.
- Certain fractures of the thigh bone (femur) have been reported in patients using bisphosphonates. It is unknown if bisphosphonates contributed to the fractures. Contact your doctor right away if you experience hip, thigh, or groin pain. Discuss any questions or concerns with your doctor.
- Alendronate solution may cause jawbone problems in some patients. Your risk may be greater the longer you take alendronate solution or if you have cancer, poor dental hygiene, ill-fitting dentures, or certain other conditions (eg, anemia, blood clotting problems, dental problems, infection). Your risk may also be greater if you have certain dental procedures or you use certain medicines or therapies (eg, chemotherapy, corticosteroids, radiation). Talk to your doctor about having a dental exam before you start to use alendronate solution. Ask your doctor any questions you may have about dental treatment while you use alendronate solution.
- Proper dental care is important while you are taking alendronate solution. Brush and floss your teeth and visit the dentist regularly.
- Alendronate solution may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to alendronate solution. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Certain dental procedures should be avoided if possible while you are using alendronate solution. Tell your doctor or dentist that you take alendronate solution before you receive any medical or dental care, emergency care, or surgery.
- Worsening of asthma has been reported in patients taking medicines like this one. Discuss any questions or concerns with your doctor.
- Lab tests, including bone density and blood calcium levels, may be performed while you use alendronate solution. These tests may be used to monitor your condition or check for side effects. Your doctor may also want to evaluate you periodically while you take alendronate solution to assess the need to continue treatment. Be sure to keep all doctor and lab appointments.
- Alendronate solution should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using alendronate solution while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use alendronate solution, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of alendronate solution:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; diarrhea; dizziness; feeling bloated or full; flu-like symptoms at the start of treatment; gas; headache; mild back, muscle, or joint pain; mild stomach pain or upset; nausea; taste changes; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); black, tarry, or bloody stools; chest pain; coughing or vomiting blood; difficult or painful swallowing; mouth sores; new, worsening, or persistent heartburn; red, swollen, blistered, or peeling skin; severe bone, muscle, or joint pain (especially in the hip, groin, or thigh); severe or persistent sore throat or stomach pain; swelling of the hands, legs, or joints; swelling or pain in the jaw; symptoms of low blood calcium (eg, spasms, twitches, or cramps in your muscles; numbness or tingling in your fingers, toes, or around your mouth).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Do not lie down. Do not try to vomit.Proper storage of alendronate solution:
Store alendronate solution at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep alendronate solution out of the reach of children and away from pets.
- If you have any questions about alendronate solution, please talk with your doctor, pharmacist, or other health care provider.
- Alendronate solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take alendronate solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about alendronate solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to alendronate solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using alendronate solution.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about alendronate
- Side Effects
- During Pregnancy or Breastfeeding
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- Drug class: bisphosphonates