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Aldurazyme

Generic Name: Laronidase (lair OH ni days)
Brand Name: Aldurazyme

Medically reviewed on September 5, 2018

Warning

  • Very bad and sometimes life-threatening allergic reactions have happened with Aldurazyme (laronidase). These reactions have happened during infusion and up to 3 hours after it is done.
  • You will be watched closely by your doctor.
  • Tell your doctor if you have lung or breathing problems. If you have a reaction to Aldurazyme (laronidase), your lung or breathing problem may get worse. Talk with your doctor.

Uses of Aldurazyme:

  • It is used to treat mucopolysaccharidosis I.

What do I need to tell my doctor BEFORE I take Aldurazyme?

  • If you have an allergy to laronidase or any other part of Aldurazyme (laronidase).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Aldurazyme (laronidase) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Aldurazyme?

  • Tell all of your health care providers that you take Aldurazyme (laronidase). This includes your doctors, nurses, pharmacists, and dentists.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Aldurazyme (laronidase) while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Aldurazyme) best taken?

Use Aldurazyme (laronidase) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.
  • Your doctor will give Aldurazyme (laronidase).
  • Other drugs may be given before Aldurazyme (laronidase) to help avoid side effects.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high or low blood pressure like very bad headache or dizziness, passing out, change in eyesight.
  • Chest pain or pressure or a fast heartbeat.
  • Slow heartbeat.
  • Shortness of breath.
  • Fever or chills.
  • A burning, numbness, or tingling feeling that is not normal.
  • Fast breathing.
  • Any unexplained bruising or bleeding.
  • Swelling.
  • Pale skin.
  • Shakiness.
  • Twitching.
  • Very bad irritation where the shot was given.
  • Change in eyesight.

What are some other side effects of Aldurazyme?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Aldurazyme?

  • If you need to store Aldurazyme (laronidase) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Aldurazyme (laronidase), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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