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Akynzeo

Generic Name: netupitant and palonosetron (net-UE-pi-tant & PAL-oh-NOE-se-tron)
Brand Name: Akynzeo

Akynzeo is used for:

Preventing nausea and vomiting caused by cancer chemotherapy.

Akynzeo is a substance P/neurokinin 1 (NK1) and 5-HT3 receptor blocker combination. It works by blocking the action of certain substances in parts of the brain and nervous system, which helps reduce or prevent nausea and vomiting.

Do NOT use Akynzeo if:

  • you are allergic to any ingredient in Akynzeo
  • you have severe kidney or liver problems
  • you are taking rifampin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Akynzeo:

Some medical conditions may interact with Akynzeo. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to other 5-HT3 receptor antagonists (eg, ondansetron)

Some MEDICINES MAY INTERACT with Akynzeo. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) or serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine) because the risk of a severe and sometimes fatal effect (serotonin syndrome) may be increased
  • Rifampin because it may decrease Akynzeo's effectiveness
  • Benzodiazepines (eg, alprazolam, triazolam), cyclophosphamide, docetaxel, etoposide, ifosfamide, imatinib, irinotecan, paclitaxel, vinblastine, vincristine, or vinorelbine because the risk of their side effects may be increased by Akynzeo

This may not be a complete list of all interactions that may occur. Ask your health care provider if Akynzeo may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Akynzeo:

Use Akynzeo as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Akynzeo. Talk to your pharmacist if you have questions about this information.
  • Take Akynzeo by mouth with or without food.
  • Take Akynzeo about 1 hour before the start of chemotherapy.
  • If you are taking another medicine called dexamethasone along with Akynzeo, be sure to take it as your doctor has told you.
  • If you miss a dose of Akynzeo, call your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use Akynzeo.

Important safety information:

  • Serotonin syndrome is a possibly fatal syndrome that can be caused by Akynzeo. Your risk may be greater if you take Akynzeo with certain other medicines (eg, certain medicines used to treat depression, pain, migraines). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Akynzeo while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while you are using Akynzeo.

Possible side effects of Akynzeo:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; headache; skin redness; tiredness; upset stomach; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Akynzeo:

Store Akynzeo at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Akynzeo out of the reach of children and away from pets.

General information:

  • If you have any questions about Akynzeo, please talk with your doctor, pharmacist, or other health care provider.
  • Akynzeo is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Akynzeo or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Akynzeo. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Akynzeo. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Akynzeo.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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