Generic Name: amprenavir (am-PREN-ah-veer)
Brand Name: Agenerase
Agenerase is used for:
Treating HIV infection. Agenerase is used in combination with other medicines.
Agenerase is an HIV-protease inhibitor. It works by inhibiting the growth of HIV.
Do NOT use Agenerase if:
- you are allergic to any ingredient in Agenerase
- you are taking astemizole, cisapride, delavirdine, an ergot derivative (eg, ergotamine), eletriptan, erythromycin, certain HMG-CoA reductase inhibitors (lovastatin, simvastatin), midazolam, nevirapine, an oral contraceptive (birth control pills), pimozide, a quinazoline (eg, alfuzosin), rifampin, St. John's wort, sumatriptan, terfenadine, or triazolam
Contact your doctor or health care provider right away if any of these apply to you.
Before using Agenerase:
Some medical conditions may interact with Agenerase. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
- if you have diabetes, hemophilia or other bleeding disorders, high cholesterol or triglyceride levels, high blood sugar, liver disease, a skin rash, or kidney problems
Some MEDICINES MAY INTERACT with Agenerase. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Carbamazepine, dexamethasone, methadone, non-nucleoside reverse transcriptase inhibitors (NNRTIs) (eg, efavirenz, nevirapine), oral contraceptives (birth control pills), phenobarbital, phenytoin, rifampin, saquinavir, or St. John's wort because the effectiveness of Agenerase may be decreased
- HIV protease inhibitors (eg, indinavir, ritonavir) because the actions and side effects of Agenerase may be increased
- Astemizole, certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), cisapride, eletriptan, ergot derivatives (eg, ergotamine), erythromycin, midazolam, pimozide, quinazolines (eg, alfuzosin), sumatriptan, terfenadine, or triazolam because the risk of side effects may be increased by Agenerase
- Aldosterone blockers (eg, eplerenone), antiarrhythmics (eg, amiodarone, bepridil, flecainide, lidocaine, propafenone, quinidine), azole antifungals (eg, itraconazole, ketoconazole), benzodiazepines (eg, alprazolam), calcium channel blockers (eg, diltiazem, amlodipine), fluoxetine, fluticasone, immunosuppressants (eg, cyclosporine, tacrolimus), muscarinic receptor antagonists (eg, darifenacin), narcotic analgesics (eg, fentanyl), rifabutin, sildenafil, trazodone, or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects may be increased by Agenerase
- Delavirdine because effectiveness may be decreased by Agenerase
- Anticoagulants (eg, warfarin) because actions and effectiveness may be altered by Agenerase
This may not be a complete list of all interactions that may occur. Ask your health care provider if Agenerase may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Agenerase:
Use Agenerase as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Agenerase may be taken with or without food. If you take it with food, do not take it with a high fat meal.
- Agenerase comes with an additional patient leaflet. Read it carefully and reread it each time you get Agenerase refilled.
- Do not take antacids or a buffered form of didanosine within 1 hour before or 1 hour after taking Agenerase.
- Continue to use Agenerase even if you feel well. Do not miss any doses.
- Do not switch between the capsule and liquid forms of Agenerase. They are not equal milligram to milligram. Consult with your doctor or pharmacist.
- If you miss a dose of Agenerase, take it as soon as possible. If you miss a dose by more than 4 hours, skip the missed dose and go back to your regular dosing schedule. It is important not to miss doses of Agenerase. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Agenerase.
Important safety information:
- Agenerase is not a cure for HIV infection and patients may continue to acquire illnesses and infections associated with HIV. Remain under the care of your doctor.
- Agenerase may not prevent other infections. If your health changes, check with your doctor.
- When your medicine supply begins to run low, get more from your doctor or pharmacist as soon as possible. The virus may develop resistance to Agenerase and become more difficult to treat if you stop taking it, even for a short period of time.
- Agenerase offers no protection from the transmission of HIV to others through sexual contact or blood contamination. Use barrier forms of contraception (eg, condoms) if you are infected with HIV. Do not share needles, other injection equipment, or personal items such as toothbrushes or razor blades.
- Certain birth control pills may decrease the effectiveness of Agenerase. Women should not take birth control pills and should use additional or other birth control measures (eg, condoms, diaphragms) while taking Agenerase.
- Do not take vitamin E supplements while you are taking Agenerase. Agenerase already contains vitamin E.
- Agenerase may cause high blood sugar (eg, thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, fruity breath odor). If these symptoms occur, tell your doctor immediately.
- Changes in body fat may occur in some patients taking this type of medicine. These changes may include increased amount of fat in the upper back and neck, breast, and around the trunk, and loss of fat from the legs, arms, and face. The cause and long-term effects are unknown. Discuss any concerns with your doctor.
- LAB TESTS, including liver function, blood cholesterol or triglyceride levels, and white blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
- Use Agenerase with caution in the ELDERLY because they may be more sensitive to its effects.
- Agenerase is not recommended for use in CHILDREN younger than 4 years of age. Safety and effectiveness in this age group have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Agenerase during pregnancy. It is unknown if Agenerase is excreted in breast milk. Do not breast-feed while taking Agenerase. HIV-infected mothers should not breast-feed their infants because of the risk of transmitting the HIV infection or Agenerase.
Possible side effects of Agenerase:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea/loose stools; headache; nausea; numbness or tingling around the mouth and in the hands and feet; rash; shift of body fat to stomach and upper back; stomach pain; taste disorders; vomiting.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in mood, emotions, or behavior; clumsiness; depression; excessive urination, thirst, or hunger; fever, chills, or sore throat; muscle pain or stiffness; red, swollen, or blistered skin; seizures; unusual tiredness or weakness; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Agenerase:
Store Agenerase at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Agenerase out of the reach of children and away from pets.
- If you have any questions about Agenerase, please talk with your doctor, pharmacist, or other health care provider.
- Agenerase is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about Agenerase. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Agenerase (amprenavir)
- Side Effects
- During Pregnancy
- Dosage Information
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- Drug class: protease inhibitors