Acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine/ guaifenesin liquid
Generic Name: acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin (a-SEET-a-MIN-oh-fen/dox-IL-a-meen/DEX-troe-meth-OR-fan/FEN-il-EF-rin/gwye-FEN-e-sin)
Brand Name: DayQuil/NyQuil Severe Cold and Flu
Acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine/ guaifenesin liquid is used for:
Relieving symptoms of fever, headache, pain, sinus congestion, runny nose, sneezing, sore throat, and cough due to colds, flu, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.
Acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid is an analgesic, antihistamine, cough suppressant, decongestant, and expectorant combination. The analgesic works in the brain to decrease pain and reduce fever. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes, runny nose, and sneezing. The cough suppressant works in the brain to reduce a dry or unproductive cough. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages, which helps relieve nasal congestion and pain associated with sinus pressure. The expectorant works by loosening mucus and thinning lung secretions in the chest, making coughs more productive.
Do NOT use acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine/ guaifenesin liquid if:
- you are allergic to any ingredient in acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid
- you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
- you are unable to urinate or are having an asthma attack
- you take droxidopa or sodium oxybate (GHB), or have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine/ guaifenesin liquid:
Some medical conditions may interact with acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a fast, slow, or irregular heartbeat
- if you have a history of liver or kidney problems; adrenal gland problems (eg, adrenal gland tumor); heart problems; high blood pressure; diabetes; blood vessel problems; stroke; glaucoma or increased pressure in the eye; a blockage of your bladder, stomach, or intestines; ulcers; trouble sleeping; trouble urinating; an enlarged prostate or other prostate problems ; seizures; or thyroid problems
- if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), sleep apnea, or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus
- if you smoke, have a history of addiction to alcohol, drink 3 or more drinks with alcohol per day, or are on a low-sodium diet
Some MEDICINES MAY INTERACT with acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Anticoagulants (eg, warfarin), digoxin, or droxidopa because risk of bleeding, irregular heartbeat, or heart attack may be increased
- Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, isoniazid, MAOIs (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid's side effects
- Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid
- Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid
This may not be a complete list of all interactions that may occur. Ask your health care provider if acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine/ guaifenesin liquid:
Use acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid by mouth with or without food.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Drinking extra fluids while you are taking acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid is recommended. Check with your doctor for instructions.
- If you miss a dose of acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid, take it as soon as you remember. Continue to take it as directed by your doctor or on the package label.
Ask your health care provider any questions you may have about how to use acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid.
Important safety information:
- Acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol while you are taking acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid.
- Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Do not take diet or appetite control medicines while you use acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid unless your doctor tells you otherwise.
- Acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid has acetaminophen, dextromethorphan, doxylamine, and phenylephrine in it. Before you start any new medicine, check the label to see if it has acetaminophen, dextromethorphan, an antihistamine, or a decongestant in it too. If it does or if you are not sure, check with your doctor or pharmacist.
- Do not use acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
- Do NOT take more than the recommended dose or take for longer than prescribed without checking with your doctor.
- If your symptoms do not get better within 7 days, if they get worse, or if they occur along with a persistent fever, check with your doctor.
- Contact your doctor if you have a sore throat that is severe, lasts more than 2 days, or occurs with fever, rash, headache, nausea, or vomiting.
- Contact your doctor if you have a fever that lasts for more than 3 days.
- Contact your doctor if you have a cough that lasts more than 7 days, goes away and then comes back, or occurs along with persistent fever, rash, or headache.
- Acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid may harm your liver. Your risk may be greater if you drink alcohol while you are using acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid. Talk to your doctor before you take acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid or other fever reducers if you drink more than 3 drinks with alcohol per day.
- Acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid for a few days before the tests.
- If you have trouble sleeping, ask your doctor or pharmacist about the best time of the day to take acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid.
- Tell your doctor or dentist that you take acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid before you receive any medical or dental care, emergency care, or surgery.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- Use acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid with caution in the ELDERLY; they may be more sensitive to its effects.
- Caution is advised when using acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid in CHILDREN; they may be more sensitive to its effects, especially excitability.
- Different brands of acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid while you are pregnant. Some of the ingredients in acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid are found in breast milk. If you are or will be breast-feeding while you use acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine/ guaifenesin liquid:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Dizziness; drowsiness; dry mouth, nose, or throat; headache; nausea; nervousness; trouble sleeping.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; mental or mood changes; pale stools; seizures; severe nervousness, drowsiness, or trouble sleeping; severe or persistent dizziness, light-headedness, or headache; severe or persistent stomach pain, nausea, or vomiting; tremor; unusual fatigue; vision changes; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid:
Store acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid out of the reach of children and away from pets.
- If you have any questions about acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid, please talk with your doctor, pharmacist, or other health care provider.
- Acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using acetaminophen/doxylamine/dextromethorphan/phenylephrine/guaifenesin liquid.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.