Generic Name: abacavir (a-BAK-a-vir)
Brand Name: Ziagen
Abacavir solution has caused severe and sometimes fatal allergic reactions. Contact your doctor right away if you develop fever; rash; nausea, vomiting, diarrhea, or stomach pain; cough, sore throat, or trouble breathing; unusual tiredness or achiness; or general feeling of being unwell. Do NOT take abacavir solution again or take any other medicine that contains abacavir if you have had an allergic reaction to abacavir solution. You may be at risk for an even more severe allergic reaction.
Patients who have a certain gene type called HLA-B*5701 have an increased risk of allergic reaction. A lab test may be performed before you start abacavir solution to see if you have this gene type. Discuss any questions or concerns with your doctor.
Abacavir solution may cause severe and sometimes fatal high blood acid levels (lactic acidosis) and liver problems. The risk of these problems may be greater if you are a woman, are very overweight, or have a history of liver problems. It may also be increased in patients who have taken certain HIV medicines for a prolonged period of time. Contact your doctor right away if you develop yellowing of the skin or eyes; dark urine; pale stools; stomach pain; nausea; vomiting; diarrhea; persistent loss of appetite; fast or difficult breathing; fast or irregular heartbeat; unusual weakness or tiredness; unusual muscle pain or tenderness; unusual feeling of cold (eg, in arms or legs); shortness of breath; sluggishness; or severe or unusual drowsiness, dizziness, or light-headedness.
Abacavir solution is used for:
Treating HIV infection with other medications.
Abacavir solution is a nucleoside analog reverse transcriptase inhibitor (NRTI). It works by slowing down the growth of HIV, the virus that causes AIDS.
Do NOT use abacavir solution if:
- you are allergic to any ingredient in abacavir solution
- you have moderate to severe liver problems
- you take another medicine that contains abacavir
Contact your doctor or health care provider right away if any of these apply to you.
Before using abacavir solution:
Some medical conditions may interact with abacavir solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding or thinking about breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of heart problems (eg, heart attack), high blood pressure, liver problems (eg, hepatitis B), high cholesterol, or diabetes
- if you smoke, drink alcohol, or are very overweight
- if you have a history of autoimmune problems (eg, Graves disease, Guillain-BarrÃ© syndrome)
- if you have been tested and know whether or not you have a gene type called HLA-B*5701
- if you have ever taken another medicine that contains abacavir
Some MEDICINES MAY INTERACT with abacavir solution. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Methadone because its effectiveness may be decreased by abacavir solution
This may not be a complete list of all interactions that may occur. Ask your health care provider if abacavir solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use abacavir solution:
Use abacavir solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Abacavir solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get abacavir solution refilled.
- Abacavir solution comes with a warning card that provides information about recognition of allergic reactions. Carry the warning card of allergy symptoms with you. Tell your health care provider immediately about any side effects you experience while taking abacavir solution.
- Take abacavir solution by mouth with or without food.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Taking abacavir solution at the same time(s) each day will help you to remember to take it.
- Take abacavir solution on a regular schedule to get the most benefit from it.
- Continue to take abacavir solution even if you feel well. Do not miss any doses.
- If you miss a dose of abacavir solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you are not sure what to do if you miss a dose, call your doctor.
Ask your health care provider any questions you may have about how to use abacavir solution.
Important safety information:
- Abacavir solution may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use abacavir solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Tell your doctor or dentist that you take abacavir solution before you receive any medical or dental care, emergency care, or surgery.
- Check with your doctor before you drink alcohol while you are using abacavir solution.
- If you must stop taking abacavir solution for any reason other than a serious allergic reaction, do not start taking abacavir solution again without talking with your health care provider. If your health care provider decides that you may take abacavir solution again, you should do so only in a setting with other people in case you need immediate access to a doctor.
- When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking abacavir solution, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
- Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking abacavir solution. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.
- Abacavir solution may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start abacavir solution.
- Abacavir solution does not stop the spread of HIV to others through blood or sexual contact. Do not have any kind of sex without protection (eg, latex or polyurethane condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HIV to others.
- Abacavir solution is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
- Do NOT take more than the recommended dose, change the dose, or stop taking abacavir solution without checking with your doctor.
- Lab tests, including liver function tests and monitoring for hypersensitivity reactions, may be performed while you use abacavir solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- If your child is taking abacavir solution, the dose may need to be changed as your child's weight changes. Have your child's weight checked often. Talk with the doctor before changing your child's dose.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using abacavir solution while you are pregnant. It is not known if this medicine is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or abacavir solution to the baby.
Possible side effects of abacavir solution:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; headache; lack of energy; loss of appetite; mild nausea; tiredness; trouble sleeping; unusual dreams; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling; change in the amount of urine produced; chest, jaw, or arm pain; ear pain; eye pain, redness, or swelling; fainting; fever or chills; mental or mood changes (eg, depression); mouth sores; red, swollen, blistered, or peeling skin; severe or persistent dizziness; severe or persistent nausea, vomiting, or diarrhea; shortness of breath, cough, or sore throat; stomach pain; swollen lymph nodes; symptoms of lactic acidosis (eg, fast breathing; fast or irregular heartbeat; unusual muscle pain or tenderness; unusual cold feeling in the arms or legs; sluggishness; severe or unusual drowsiness, dizziness, or light-headedness); symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools, persistent loss of appetite); unusual achiness, sweating, or swelling; unusual tiredness or weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of abacavir solution:
Store abacavir solution at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep abacavir solution out of the reach of children and away from pets.
- If you have any questions about abacavir solution, please talk with your doctor, pharmacist, or other health care provider.
- Abacavir solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take abacavir solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about abacavir solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to abacavir solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using abacavir solution.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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- Drug class: nucleoside reverse transcriptase inhibitors (NRTIs)
Other brands: Ziagen