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Abacavir, dolutegravir, and lamivudine

Generic Name: abacavir, dolutegravir, and lamivudine (a-BAK-a-vir, DOE-loo-TEG-ra-vir, & la-MIV-ue-deen)
Brand Name: Triumeq

Abacavir, dolutegravir, and lamivudine has caused severe and sometimes fatal allergic reactions. Contact your doctor right away if you develop fever; rash; nausea, vomiting, diarrhea, or stomach pain; cough, sore throat, or trouble breathing; unusual tiredness or achiness; or general feeling of being unwell. Do NOT take abacavir, dolutegravir, and lamivudine again or take any other medicine that contains abacavir if you have had an allergic reaction to abacavir, dolutegravir, and lamivudine. You may be at risk for an even more severe allergic reaction. If you stop taking abacavir, dolutegravir, and lamivudine for any other reason, even for a few days, and you are not allergic to it, check with your doctor before restarting it.

Patients who have a certain gene type called HLA-B*5701 have an increased risk of having an allergic reaction to abacavir. A lab test may be performed before you start abacavir, dolutegravir, and lamivudine to see if you have this gene type. Discuss any questions or concerns with your doctor.

High levels of lactic acid in the blood (lactic acidosis) and severe liver problems, including fatal cases, have been reported in patients taking certain HIV medicines, such as abacavir, dolutegravir, and lamivudine. The risk may be greater in women, in patients who are very overweight, or in patients who have a history of liver problems. It may also be increased in patients who have taken certain HIV medicines for a prolonged period of time. Call your doctor right away if you have symptoms of lactic acidosis (eg, fast or irregular heartbeat; feeling cold, especially in your arms and legs; rapid or difficult breathing; severe or unusual drowsiness, dizziness, or light-headedness; sluggishness; stomach pain with nausea or vomiting; unusual muscle pain or tenderness; unusual tiredness or weakness). Call your doctor right away if you have symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, stomach pain, yellowing of the eyes or skin).

Severe worsening of hepatitis B virus (HBV) has been reported in patients who have both HIV and HBV infection and have stopped taking lamivudine. Patients who have both HIV and HBV infection need close medical follow-up to check for worsening liver problems for at least several months after stopping lamivudine. Be sure to keep all doctor and lab appointments.


Abacavir, dolutegravir, and lamivudine is used for:

Treating HIV infection.

Abacavir, dolutegravir, and lamivudine is a combination of an HIV-1 integrase strand transfer inhibitor (INSTI) and 2 nucleoside analogue reverse transcriptase inhibitors (NRTIs). The INSTI works by blocking HIV-1 integrase, an enzyme needed for the HIV virus to replicate. The NRTIs work by blocking HIV from reproducing.

Do NOT use abacavir, dolutegravir, and lamivudine if:

  • you are allergic to any ingredient in abacavir, dolutegravir, and lamivudine
  • you have been tested and know that you have a gene type called HLA-B*5701
  • you have kidney problems, or moderate or severe liver problems
  • you are taking carbamazepine, dofetilide, nevirapine, oxcarbazepine, phenobarbital, phenytoin, or St. John's wort
  • you are taking another medicine that contains abacavir, emtricitabine, or lamivudine

Contact your doctor or health care provider right away if any of these apply to you.

Before using abacavir, dolutegravir, and lamivudine:

Some medical conditions may interact with abacavir, dolutegravir, and lamivudine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of kidney problems, heart problems (eg, a heart attack), high blood pressure, high cholesterol, diabetes, pancreatitis, liver problems (eg, hepatitis B or C infection), or nerve problems
  • if you have a history of high levels of lactic acid in the blood or are at risk of liver problems
  • if you smoke, drink alcohol, or are very overweight
  • if you are taking any other medicine for HIV infection
  • if you have been tested and know whether or not you have a gene type called HLA-B*5701

Some MEDICINES MAY INTERACT with abacavir, dolutegravir, and lamivudine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Dofetilide because the risk of serious and sometimes fatal side effects may be increased
  • Interferon alfa with or without ribavirin because it may increase the risk of side effects (eg, worsening of liver disease)
  • Carbamazepine, efavirenz, etravirine, fosamprenavir, nevirapine, oxcarbazepine, phenobarbital, phenytoin, rifamycins (eg, rifampin), St. John's wort, or tipranavir because they may decrease abacavir, dolutegravir, and lamivudine's effectiveness
  • Methadone because its effectiveness may be decreased by abacavir, dolutegravir, and lamivudine
  • Metformin because the risk of its side effects may be increased
  • Other medicines that contain abacavir, emtricitabine, or lamivudine because the risk of side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if abacavir, dolutegravir, and lamivudine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use abacavir, dolutegravir, and lamivudine:

Use abacavir, dolutegravir, and lamivudine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Abacavir, dolutegravir, and lamivudine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get abacavir, dolutegravir, and lamivudine refilled.
  • Abacavir, dolutegravir, and lamivudine comes with a warning card that provides information about recognition of allergic reactions. Carry the warning card of allergy symptoms with you. Tell your health care provider immediately about any side effects you experience while taking abacavir, dolutegravir, and lamivudine.
  • Take abacavir, dolutegravir, and lamivudine by mouth with or without food.
  • Do not take an antacid or product that has magnesium, aluminum, iron, or calcium; sucralfate; or buffered medicines within 6 hours before or 2 hours after you take abacavir, dolutegravir, and lamivudine.
  • Taking abacavir, dolutegravir, and lamivudine at the same time each day will help you remember to take it.
  • Take abacavir, dolutegravir, and lamivudine on a regular schedule to get the most benefit from it.
  • Continue to take abacavir, dolutegravir, and lamivudine even if you feel well. Do not miss any doses.
  • If you miss a dose of abacavir, dolutegravir, and lamivudine, take it as soon as possible. If it is within 4 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you are not sure what to do if you miss a dose of abacavir, dolutegravir, and lamivudine, call your doctor.

Ask your health care provider any questions you may have about how to use abacavir, dolutegravir, and lamivudine.

Important safety information:

  • Tell your doctor or dentist that you take abacavir, dolutegravir, and lamivudine before you receive any medical or dental care, emergency care, or surgery.
  • Drinking alcohol while taking abacavir, dolutegravir, and lamivudine may cause an increased risk of side effects. Talk to your doctor before drinking alcohol while you are taking abacavir, dolutegravir, and lamivudine.
  • Abacavir, dolutegravir, and lamivudine is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
  • When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking abacavir, dolutegravir, and lamivudine, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
  • If you stop taking abacavir, dolutegravir, and lamivudine even for a few days (eg, if you run out of your medicine and do not get it refilled right away), contact your doctor before you start taking it again. You may experience a serious allergic reaction if you stop taking abacavir, dolutegravir, and lamivudine and then start again.
  • Abacavir, dolutegravir, and lamivudine does not stop the spread of HIV to others through blood or sexual contact. Do not have any kind of sex without protection (eg, latex or polyurethane condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HIV to others.
  • Abacavir, dolutegravir, and lamivudine may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start abacavir, dolutegravir, and lamivudine.
  • Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking abacavir, dolutegravir, and lamivudine. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.
  • Lab tests may be performed while you use abacavir, dolutegravir, and lamivudine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking abacavir, dolutegravir, and lamivudine while you are pregnant. Abacavir, dolutegravir, and lamivudine is found in breast milk. Do not breast-feed while taking abacavir, dolutegravir, and lamivudine. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or abacavir, dolutegravir, and lamivudine to the baby.

Possible side effects of abacavir, dolutegravir, and lamivudine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; tiredness; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (fever; rash; tiredness; achiness; nausea; diarrhea; vomiting; stomach pain; sore throat; hives; itching; difficulty breathing; cough; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling; chest, jaw, or arm pain or discomfort; decreased urination; fainting; mouth or eye sores or blisters; muscle or joint aches; red, swollen, blistered, or peeling skin; redness or swelling of the eyes; severe or persistent dizziness; shortness of breath; swelling; swollen lymph nodes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of abacavir, dolutegravir, and lamivudine:

Store abacavir, dolutegravir, and lamivudine in the original bottle at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Keep the bottle tightly closed. Do not remove the anti-moisture packet. Store away from heat, moisture, and light. Do not store in the bathroom. Keep abacavir, dolutegravir, and lamivudine out of the reach of children and away from pets.

General information:

  • If you have any questions about abacavir, dolutegravir, and lamivudine, please talk with your doctor, pharmacist, or other health care provider.
  • Abacavir, dolutegravir, and lamivudine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take abacavir, dolutegravir, and lamivudine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about abacavir, dolutegravir, and lamivudine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to abacavir, dolutegravir, and lamivudine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using abacavir, dolutegravir, and lamivudine.

Review Date: November 3, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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