... I took zoloft years ago, switched to lexapro for perhaps 9 years, then off lex and now back it at 20 mg due to anxiety which was followed by depression and panic. On the lex plus 1 mg klonopin for 5 weeks or so, moved from 10 to 15 and 2 days ago to 20. I have side effects every time I up the dose, had little to none when first on it and it worked well before at 10 and even 5 mg after I was well for some years. If the lex doesnt work, would it be worth trying zoloft again? I liked lex better than zoloft, the latter bothered my stomach and sleep to some degree but it did work.