I have been taking zoloft since I was 17 1/2 years old and will be 21 soon. I am no where depressed at all anymore but continue taking the medicine. I had been taking 100mg but decreased to 75mg in august and recently started taking only 50mg in December. I am very intune with my body and just wondering if this is has caused fatigue for others? Please post your experiences and how you have overcome the fatigue.