I started Zoloft at 25mg to help with my anxiety and depression. It seemed to be working immediately. I woke up in the morning calmer and didn't feel the familiar suffocating feeling in my brain. It's also possible that after 5 years of therapy, I have made progress. After 2-3 weeks on Zoloft, the anxious feelings are back and I wonder if I need to go up to 50mg or perhaps it never was working, to begin with. Is it normal to see results so soon? Does the efficacy taper off each time the dose gets raised?
Hi, Tziker! Honestly, it's unlikely to feel improvement until after several weeks of therapy and it usually take 4-6 weeks to see significant improvement and 6-8 weeks for the drug to reach maximum therapeutic levels in your blood/brain. Many people do experience a placebo effect, but that generally wears off with time.
25mg is a very low initial dose prescribed to get your metabolism used to the drug and to avoid the potential initial side effects. An increase is probably indicated for you as you can see at this link:
I'd talk with your doctor about your current anxiety and get her/his professional recommendation.
Best regards, Wildcat
P.S., Good for you for sticking it out with therapy! In addition to my medications it's made a world of difference helping me cope.
- Zoloft Information for Consumers
- Zoloft Information for Healthcare Professionals (includes dosage details)
- Side Effects of Zoloft (detailed)
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