I've been off and on Cymbalta for 6 years. The reason I go off is I get tired of urgent urinating and peeing on myself because I can't move fast enough. It also elevates blood sugar levels and I'm Diabetic Type II. I've read a study that Zoloft is 30% more effective than Cymbalta, but won't change if it has the same side effects. I can't go near running water, have to pee when I'm just pouring liquids and am really tired of this piss problem. Didn't happen when I went off Cymbalta, but other anti-depressants haven't worked.