... its effect of using combination therapy
Combinations of levofloxacin and colistin (2 μg/ml) or azithromycin did not reduce the mutational frequencies relative to that for levofloxacin alone
but there is a data to use a combination of macrolide and flouroquinolone in extra-pulmonary legionnaires resistant to treatment by one but no enough data to select which combination is perfect . as well the risk of QTc prolongation is high with this combination so consider therapy modification
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