I have had some problems with reflux and heartburn off and on for nearly a year. I'm a 66 year old female. I took Prilosec for a few months and was sicker than ever, so I weaned off it. so I have the Zantac 150 which I can take twice a day when needed. I feel crazy, but sometimes it makes my heartburn worse! anyone else have this problem? I have totally given up on doctors.