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Why can't you take Zantac and Nexium together?

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masso 3 May 2016

Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Duplication
Acid suppressant agents
Therapeutic duplication
The recommended maximum number of medicines in the 'acid suppressant agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'acid suppressant agents' category:
esomeprazole (active ingredient in Nexium (esomeprazole))
ranitidine (active ingredient in Zantac (ranitidine))
Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

https://www.drugs.com/interactions-check.php?drug_list=1015-567,1991-1283

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