To my surprise, hydroxyzine and topamax have a major interaction. It basically causes overheating. Now, sometimes the interactions checker is a little dramatic and your doc may prescribe it anyways. If doc says to do it, do it. The pseudoephedrine doesn’t interact with either. If you take the topamax as a mood stabilizer, pseudoephedrine may increase your mood, but that doesn’t have anything to do with the drug interaction. Bipolar people sometimes just can’t take pseudoephedrine.
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