I take melatonin at night and prescribed vicodin extra strength for my surgery...
Yes you can take both melatonin and Vicodin ES together. My doctor actually advised me to take the two together years ago. I am not a doctor or nurse, but as far as I know, it is still ok to take the two together. If you are really concerned about it you can call a pharmacist and ask them, they are the best resource to ask about what medications are safe to mix.
Good luck... and take care!!
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