Hi, johns! As far as I know (and I very well might be wrong!!) Nuedexta is only currently approved for a rare neurological condition, pseudobulbar affect or PBA. The emotional symptoms resemble depression.
Clinical studies are being done to test it's efficacy in treating drug-resistant depression, and apparently some doctors are prescribing Nuedextra off-label.
I haven't read any of the forums or anyone's comments about it works for them. You could Google *nuedextra for depression*.
Good luck! WCV
Nuedexta contains a combination of dextromethorphan and quinidine. Dextromethorphan affects the signals in the brain that trigger cough reflex and is generally used as a cough suppressant.
Quinidine affects the way that the heart beats and is generally used to in people with certain heart rhythm disorders.
Nuedexta is used to treat involuntary outbursts of crying or laughing in people with certain neurological disorders, including multiple sclerosis and amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease).
Nuedexta may also be used for purposes not listed in this medication guide.
I hope that helps.
I was prescribed NUEDEXTA "off label" for depression and it worked for me in 10 days.
I had been on CYMBALTA & ABILIFY but they really weren't helping me as I continued to be seriously depressed (as a result of a traumatic brain injury and a stroke). The neurologist I saw is *highly acclaimed" within the medical community for his expertise and in the waiting room I spoke to a patient that just raved about him.
The neurologist told me that he had prescribed NUEDEXTA to 200 patients that were depressed. (I don't know if their depression was a result of a neurological disability)
Of those 200 patients, five (5) patients experienced side effects. Four (4) patients' side effects stopped between three (3) days and one (1) month. One patient did not experience any change in his level of depression.
He told me that one (1) patient excitedly called him two (2) days after her appointment to let him know she was already feeling better. She was so excited because she had been on the "antidepressant rollercoaster" for such a long time, nothing worked and here she already felt better within two (2) days.
The neurologist said that he could not estimate how long it would take NUEDEXTA to work or even if it would work as he did have that one (1) patient where NUEDEXTA didn't work. The time frame varied by individual.
As I noted above, it took ten (10) days for me. I admit I was surprised since I had also been on the "antidepressant rollercoaster" for a long time.
I was lucky to have been referred to this neurologist by my neurologist.
I learned at the end of my appointment (which lasted 90 min) that he was involved in the development of NUEDEXTA and in all three (3) clinical phase trials before the drug's approval by the FDA.
Since he had been so involved in the research and development of NUEDEXTA I felt secure in using an "off label" rx. I am so glad I did. I have been using NUEDEXTA for six (6) months.
It certainly helped me and I would not hesitate recommending it for depression. The biggest drawback is the price of the drug but it made such a difference in my life that I am willing to skimp on something else so I can afford the drug.
- Nuedexta Information for Consumers
- Nuedexta Information for Healthcare Professionals (includes dosage details)
- Side Effects of Nuedexta (detailed)
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