Hi, johns! As far as I know (and I very well might be wrong!!) Nuedexta is only currently approved for a rare neurological condition, pseudobulbar affect or PBA. The emotional symptoms resemble depression.
Clinical studies are being done to test it's efficacy in treating drug-resistant depression, and apparently some doctors are prescribing Nuedextra off-label.
I haven't read any of the forums or anyone's comments about it works for them. You could Google *nuedextra for depression*.
Good luck! WCV
Nuedexta contains a combination of dextromethorphan and quinidine. Dextromethorphan affects the signals in the brain that trigger cough reflex and is generally used as a cough suppressant.
Quinidine affects the way that the heart beats and is generally used to in people with certain heart rhythm disorders.
Nuedexta is used to treat involuntary outbursts of crying or laughing in people with certain neurological disorders, including multiple sclerosis and amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease).
Nuedexta may also be used for purposes not listed in this medication guide.
I hope that helps.
I was prescribed NUEDEXTA "off label" for depression and it worked for me in 10 days.
I had been on CYMBALTA & ABILIFY but they really weren't helping me as I continued to be seriously depressed (as a result of a traumatic brain injury and a stroke). The neurologist I saw is *highly acclaimed" within the medical community for his expertise and in the waiting room I spoke to a patient that just raved about him.
The neurologist told me that he had prescribed NUEDEXTA to 200 patients that were depressed. (I don't know if their depression was a result of a neurological disability)
Of those 200 patients, five (5) patients experienced side effects. Four (4) patients' side effects stopped between three (3) days and one (1) month. One patient did not experience any change in his level of depression.
He told me that one (1) patient excitedly called him two (2) days after her appointment to let him know she was already feeling better. She was so excited because she had been on the "antidepressant rollercoaster" for such a long time, nothing worked and here she already felt better within two (2) days.
The neurologist said that he could not estimate how long it would take NUEDEXTA to work or even if it would work as he did have that one (1) patient where NUEDEXTA didn't work. The time frame varied by individual.
As I noted above, it took ten (10) days for me. I admit I was surprised since I had also been on the "antidepressant rollercoaster" for a long time.
I was lucky to have been referred to this neurologist by my neurologist.
I learned at the end of my appointment (which lasted 90 min) that he was involved in the development of NUEDEXTA and in all three (3) clinical phase trials before the drug's approval by the FDA.
Since he had been so involved in the research and development of NUEDEXTA I felt secure in using an "off label" rx. I am so glad I did. I have been using NUEDEXTA for six (6) months.
It certainly helped me and I would not hesitate recommending it for depression. The biggest drawback is the price of the drug but it made such a difference in my life that I am willing to skimp on something else so I can afford the drug.
I have heard of taking Nuedexta to treat depression. In the US, that would currently be an off-label use, as it's not approved by the FDA for that diagnosis. But it makes sense that it would work, and there may be studies underway for depression-specific formulations currently (probably higher doses of dextromethorphan with the same dose of quinidine).
Dextromethorphan acts as an antidepressant, but is rapidly metabolized by the body, so the effect doesn't last. Quinidine not only dramatically reduces the rate at which dextromethorphan is metabolized, but it also enhances dextromethorphan's effectiveness.
Another drug combo (investigational, currently) also does this, plus more: dextromethorphan plus bupropion. It includes the additional antidepressive effects of bupropion. Here, the bupropion has a dual role: it slows the metabolism of dextromethorphan and adds its own antidepressive benefits.
However, bupropion can be problematic for some people. The bupropion dose in the drug trials is 150 mg/dose, taken twice daily. When I tried bupropion, even 100 mg prevented me from sleeping. 75 mg was not a problem for my sleep, but it also didn't help with depression. In full disclosure, I was also taking Cymbalta 60 mg bid. On the other hand, someone I know well takes 200 mg bupropion once or twice/day with other antidepressants and has no sleep problems.
I also want to respond to the person who thought another's answer was actually from a drug rep, not a patient. I see what you are saying: it sounds too positive and enthusiastic, with too much data. Doctors involved in clinical trials are not like regular doctors. They're not just about treating patients. They're about, yes, making money, but also proving their science and improving public health, and that requires attention to detail, recording and studying every interaction with a patient, statistical analysis, and much more. So I don't find it surprising at all that such a doctor would recall and discuss such numbers and incidents.
Furthermore, a patient who, after years of failed antidepressive treatments, finds one that finally works, will naturally be very enthusiastic about it.
- Nuedexta Information for Consumers
- Nuedexta Information for Healthcare Professionals (includes dosage details)
- Side Effects of Nuedexta (detailed)
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