I have had RA FOR 12 years, very well controlled and mainly inactive due to Methotrexate treatment. I have had no success with any antihistamines this spring for seasonal hayfever. Tried xyzal and have been taking for about a month with some success. However I have experienced pain in hands and feet, fatigue and the worst RA flare since diagnosis. I have developed my first nodule on knuckle and am in constant pain. The only thing that has changed in my life is the introduction of s daily dose of xyzal.