... I started Xyrem two nights ago taking 2.25 twice a night. The first night I woke up an hour before I could take my second dose. After the night, I felt like I had energy but that I did not sleep. I ended up spending most of the day in bed with the jitters/ shakes and feeling off. Last night, I took the dose and again felt like I was in and out of sleep all night. My mom said she heard me stumbling around when I got up to go the bathroom. I woke up feeling out of it and called out of work. I hate not feeling like I have control of my body. I can't keep calling out of work either. How long does it take to adjust? I feel like I have spent my whole weekend in bed.