... When do you know that treatment has worked or is working? My husband's doctor prescribed this for treatment of SIBO two months ago and is not available for follow up. He prescribed this in conjunction with Amitiza 24 mcg capsules, also 2x per, along with Ducalax (3 pills 2x per). The cycle runs through 3 days of constipation and then 3 days of diarrhea. Usually to break the constipation we also add liquid Milk of Magnesia. Is there anything easier that you can recommend?