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Will coumadin interact with glimeperide?

Responses (1)

Anonymous 21 Aug 2010


Yes, they interact.-

Interactions between your selected drugs moderate

warfarin ↔ glimepiride
Applies to: Coumadin (warfarin), glimepiride
MONITOR: The hypoglycemic action of glimepiride may be potentiated by highly protein-bound drugs. The mechanism is displacement of glimepiride from protein-binding sites, resulting in higher plasma concentrations of unbound glimepiride available to act on pancreatic beta cells.

MANAGEMENT: Patients should be monitored closely for hypoglycemia during concomitant therapy, particularly following addition of a highly protein-bound drug to a stabilized glimepiride regimen. Patients should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs. Likewise, such patients should be observed for loss of glycemic control when the highly protein-bound drug is withdrawn.

Take care and have a good weekend.-

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