No, your wife does not need to avoid Vitamin K.
This is from https://www.drugs.com/aggrenox.html
"... What should I avoid while taking Aggrenox?
Avoid drinking alcohol while you are taking aspirin. Alcohol may increase your risk of stomach bleeding. Do not use any other over-the-counter pain medication without first asking your doctor or pharmacist. Aspirin, salicylates, and NSAIDs (non-steroidal anti-inflammatory drugs) are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of a certain type of drug. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, naproxen, ketoprofen, magnesium and/or choline salicylate."
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