There is no major interaction between Synthroid and weight loss medicines (2 examples done in link below).
Alli (orlistat) may interfere with the absorption of Synthroid but if you take Alli 4 hours apart from the Synthroid dose it should be fine.
- Synthroid Information for Consumers
- Synthroid Information for Healthcare Professionals (includes dosage details)
- Side Effects of Synthroid (detailed)
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