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Why nitrate free interval is required in oral dosage form?

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Marvell 27 Sep 2009

Repeated administration of nitrates results in diminished relaxation of smooth muscle in blood vessels, tolerance and unwanted effects.

The main adverse effects of nitrates are a direct consequences of their main pharmacological actions and include postural hypotension and headache. Tolerance to these effects develops quite quickly but wears off after a brief nitrate free period of a few hours in each 24 hour period, making it beneficial in maintaining effectiveness of treatment.

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