Hello hhs. I can't come up with a definite 100% answer to your question but my best guess, and in this case its just that, you'd be taking away from the manner in which Deplin works in your system. It might be loosing its potency. (most probable) but why not the occasional drink I"ve not an answer. I know its recommened to avoid alcohol while taking Deplin. I might suggest you ask your doctor or pharmacist, for they'd most certainly beable to give you a definite answer.best to you,
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